Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3738282..3738939 Replicon chromosome
Accession NZ_CP083857
Organism Enterobacter kobei strain 12379-yvys

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag LCD50_RS17755 Protein ID WP_014885136.1
Coordinates 3738282..3738692 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag LCD50_RS17760 Protein ID WP_010435322.1
Coordinates 3738673..3738939 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD50_RS17735 (LCD50_17765) 3734276..3736009 - 1734 WP_023331239.1 single-stranded-DNA-specific exonuclease RecJ -
LCD50_RS17740 (LCD50_17770) 3736015..3736728 - 714 WP_014885133.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LCD50_RS17745 (LCD50_17775) 3736757..3737653 - 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
LCD50_RS17750 (LCD50_17780) 3737755..3738276 + 522 WP_014885135.1 flavodoxin FldB -
LCD50_RS17755 (LCD50_17785) 3738282..3738692 - 411 WP_014885136.1 protein YgfX Toxin
LCD50_RS17760 (LCD50_17790) 3738673..3738939 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
LCD50_RS17765 (LCD50_17795) 3739234..3740214 + 981 WP_014885137.1 tRNA-modifying protein YgfZ -
LCD50_RS17770 (LCD50_17800) 3740299..3740958 - 660 WP_023331242.1 hemolysin III family protein -
LCD50_RS17775 (LCD50_17805) 3741224..3741955 + 732 WP_014885139.1 MurR/RpiR family transcriptional regulator -
LCD50_RS17780 (LCD50_17810) 3742072..3743505 + 1434 WP_014885140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T217577 WP_014885136.1 NZ_CP083857:c3738692-3738282 [Enterobacter kobei]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T217577 NZ_CP114374:c4853738-4853373 [Pseudomonas aeruginosa]
GTGGCGTGGGATATCGAGTACACCGACGAGTTCGGTGATTGGTGGGGTTCTCTGTCCGAGGATGAGCAGGAGTCGCTAGC
TGTGACGGTTCGCTTGCTTGAGGAGCGAGGGCCATCCTTGGGGCACCTCCACAGCAGCGGCATCAATGGCTCCCGCCATG
GCCATATGAGAGAGCTACGGACTCAACACGGCGGGCGACCTTTCCGAACGCTTTACGCGTTTGATCCCAGACGCTCCGCG
ATACTGCTGATCGGTGGCGACAAGACTGGCGATGATCGTTGGTACGAATTGGACGTGCCCATTGCCGACCGCCTCTATGA
CGAACACTTGCACCAGCTCCGTGAGGAGGGACTGATCGATGGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT217577 WP_010435322.1 NZ_CP083857:c3738939-3738673 [Enterobacter kobei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT217577 NZ_CP114374:c4853380-4853057 [Pseudomonas aeruginosa]
ATGGCTAAGAAATTCTCCGACCTTCGGGCGCAAATGTCGCCTGAGGGACAGGCCCGCGTCGAGGCCAAGGCCCAGGAACT
GTTGGCTGAAATGCCCCTGAATGAGTTGCGCCAGGCTAGAGGCTTGTCGCAGAAGATGCTGTCTGAAGTGCTGCACGTGC
AGCAGCCGGCAATTGCCAAAATGGAGCGGCGTACGGATATGTACATCTCCACCTTGCGCAGCCACATCGAAGCCATGGGC
GGCCAACTGGAAGTGATTGCACGCTTCCCGGATGGCGCGGTGAAAATCAGCAACTTCGCGGATATCGAAGAGGCGGGCGC
CTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References