Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 239648..240174 | Replicon | plasmid p12795_1 |
| Accession | NZ_CP083854 | ||
| Organism | Enterobacter roggenkampii strain 12795-yvys | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | LCD45_RS23790 | Protein ID | WP_000323025.1 |
| Coordinates | 239648..239935 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | LCD45_RS23795 | Protein ID | WP_000534858.1 |
| Coordinates | 239935..240174 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LCD45_RS23755 (LCD45_23800) | 235218..235394 | - | 177 | WP_001371930.1 | hypothetical protein | - |
| LCD45_RS23760 (LCD45_23805) | 235905..236849 | + | 945 | WP_000778029.1 | DUF5417 domain-containing protein | - |
| LCD45_RS23765 (LCD45_23810) | 236945..237547 | + | 603 | WP_001371889.1 | hypothetical protein | - |
| LCD45_RS23770 (LCD45_23815) | 237607..237957 | + | 351 | WP_000743059.1 | hypothetical protein | - |
| LCD45_RS23775 (LCD45_23820) | 238004..238207 | + | 204 | WP_001015183.1 | hypothetical protein | - |
| LCD45_RS23780 (LCD45_23825) | 238489..238809 | + | 321 | WP_000332796.1 | hypothetical protein | - |
| LCD45_RS23785 (LCD45_23830) | 239422..239547 | - | 126 | WP_229020258.1 | DUF5431 family protein | - |
| LCD45_RS23790 (LCD45_23840) | 239648..239935 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| LCD45_RS23795 (LCD45_23845) | 239935..240174 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| LCD45_RS23800 (LCD45_23850) | 240199..240303 | + | 105 | Protein_246 | protein YdfV | - |
| LCD45_RS23805 (LCD45_23855) | 240437..241360 | - | 924 | WP_000167917.1 | cation diffusion facilitator family transporter | - |
| LCD45_RS23810 (LCD45_23860) | 241560..242132 | - | 573 | WP_001515348.1 | cytochrome b/b6 domain-containing protein | - |
| LCD45_RS23815 (LCD45_23865) | 242608..243846 | - | 1239 | WP_000219087.1 | IS110-like element ISEsa2 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | ant(2'')-Ia / aadA2 / qacE / sul1 / qnrA1 / tet(A) / blaSHV-12 / catA1 / dfrA16 / blaCTX-M-9 / mcr-9 | - | 1..297683 | 297683 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T217562 WP_000323025.1 NZ_CP083854:c239935-239648 [Enterobacter roggenkampii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T217562 NZ_CP114361:c5491318-5490935 [Klebsiella variicola]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTAAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTGATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAACTACACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTAAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTGATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAACTACACCCTGAATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT217562 WP_000534858.1 NZ_CP083854:c240174-239935 [Enterobacter roggenkampii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT217562 NZ_CP114361:c5491560-5491318 [Klebsiella variicola]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|