Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3878542..3879199 Replicon chromosome
Accession NZ_CP083853
Organism Enterobacter roggenkampii strain 12795-yvys

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag LCD45_RS18390 Protein ID WP_021242050.1
Coordinates 3878542..3878952 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag LCD45_RS18395 Protein ID WP_006178375.1
Coordinates 3878933..3879199 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD45_RS18370 (LCD45_18395) 3874535..3876268 - 1734 WP_045335242.1 single-stranded-DNA-specific exonuclease RecJ -
LCD45_RS18375 (LCD45_18400) 3876274..3876987 - 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LCD45_RS18380 (LCD45_18405) 3877016..3877912 - 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
LCD45_RS18385 (LCD45_18410) 3878014..3878535 + 522 WP_045335241.1 flavodoxin FldB -
LCD45_RS18390 (LCD45_18415) 3878542..3878952 - 411 WP_021242050.1 protein YgfX Toxin
LCD45_RS18395 (LCD45_18420) 3878933..3879199 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
LCD45_RS18400 (LCD45_18425) 3879494..3880474 + 981 WP_045335240.1 tRNA-modifying protein YgfZ -
LCD45_RS18405 (LCD45_18430) 3880559..3881218 - 660 WP_045335239.1 hemolysin III family protein -
LCD45_RS18410 (LCD45_18435) 3881484..3882215 + 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
LCD45_RS18415 (LCD45_18440) 3882332..3883765 + 1434 WP_044597684.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T217559 WP_021242050.1 NZ_CP083853:c3878952-3878542 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T217559 NZ_CP114361:c4166429-4166112 [Klebsiella variicola]
ATATTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAAATAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTATGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT217559 WP_006178375.1 NZ_CP083853:c3879199-3878933 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT217559 NZ_CP114361:c4166119-4165832 [Klebsiella variicola]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCGTTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGTGGAATAAAGCACCCACAAATTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References