Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 1589036..1589949 Replicon chromosome
Accession NZ_CP083853
Organism Enterobacter roggenkampii strain 12795-yvys

Toxin (Protein)


Gene name - Uniprot ID A0A8B2SFJ4
Locus tag LCD45_RS07445 Protein ID WP_045334129.1
Coordinates 1589036..1589509 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A8B2SER9
Locus tag LCD45_RS07450 Protein ID WP_023327017.1
Coordinates 1589506..1589949 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD45_RS07425 (LCD45_07450) 1585196..1586506 + 1311 WP_046092263.1 type I-F CRISPR-associated protein Csy1 -
LCD45_RS07430 (LCD45_07455) 1586503..1587438 + 936 WP_045334125.1 type I-F CRISPR-associated protein Csy2 -
LCD45_RS07435 (LCD45_07460) 1587452..1588450 + 999 WP_045334127.1 type I-F CRISPR-associated protein Csy3 -
LCD45_RS07440 (LCD45_07465) 1588460..1589014 + 555 WP_023327015.1 type I-F CRISPR-associated endoribonuclease Cas6/Csy4 -
LCD45_RS07445 (LCD45_07470) 1589036..1589509 - 474 WP_045334129.1 RES domain-containing protein Toxin
LCD45_RS07450 (LCD45_07475) 1589506..1589949 - 444 WP_023327017.1 DUF2384 domain-containing protein Antitoxin
LCD45_RS07455 (LCD45_07480) 1590749..1590967 - 219 WP_002211347.1 translation initiation factor IF-1 -
LCD45_RS07460 (LCD45_07485) 1591252..1591956 - 705 WP_008499991.1 leucyl/phenylalanyl-tRNA--protein transferase -
LCD45_RS07465 (LCD45_07490) 1592002..1593723 - 1722 WP_021240888.1 cysteine/glutathione ABC transporter ATP-binding protein/permease CydC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-144)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17539.85 Da        Isoelectric Point: 5.0700

>T217550 WP_045334129.1 NZ_CP083853:c1589509-1589036 [Enterobacter roggenkampii]
MIFYRLVTGRYASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHVRKDTVLNQYQLFSIDIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPAFHSALNSVQQLPFIFDTRLAEKTAP

Download         Length: 474 bp

>T217550 NZ_CP114358:1287-1604 [Klebsiella variicola]
ATATTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAAATAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTATGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16352.68 Da        Isoelectric Point: 7.2062

>AT217550 WP_023327017.1 NZ_CP083853:c1589949-1589506 [Enterobacter roggenkampii]
MRTWIPAQKPADNALWRYAGLPANRGMRLIEFLNQGLPVSVLDNIHEWTSMSKADILRVTGINERNVARRKSAGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWTWLQAPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Download         Length: 444 bp

>AT217550 NZ_CP114358:1597-1884 [Klebsiella variicola]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCGTTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGTGGAATAAAGCACCCACAAATTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B2SFJ4

Antitoxin

Source ID Structure
AlphaFold DB A0A8B2SER9

References