Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1111408..1112028 Replicon chromosome
Accession NZ_CP083853
Organism Enterobacter roggenkampii strain 12795-yvys

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag LCD45_RS05200 Protein ID WP_008499287.1
Coordinates 1111408..1111626 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag LCD45_RS05205 Protein ID WP_008499288.1
Coordinates 1111654..1112028 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD45_RS05170 (LCD45_05195) 1107421..1107681 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
LCD45_RS05175 (LCD45_05200) 1107684..1107824 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LCD45_RS05180 (LCD45_05205) 1107821..1108531 - 711 WP_045335404.1 GNAT family protein -
LCD45_RS05185 (LCD45_05210) 1108633..1110093 + 1461 WP_045335405.1 PLP-dependent aminotransferase family protein -
LCD45_RS05190 (LCD45_05215) 1110065..1110532 - 468 WP_008499285.1 YlaC family protein -
LCD45_RS05195 (LCD45_05220) 1110650..1111201 - 552 WP_045335406.1 maltose O-acetyltransferase -
LCD45_RS05200 (LCD45_05225) 1111408..1111626 - 219 WP_008499287.1 HHA domain-containing protein Toxin
LCD45_RS05205 (LCD45_05230) 1111654..1112028 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
LCD45_RS05210 (LCD45_05235) 1112538..1115684 - 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit AcrB -
LCD45_RS05215 (LCD45_05240) 1115707..1116900 - 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T217549 WP_008499287.1 NZ_CP083853:c1111626-1111408 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T217549 NZ_CP114356:c14256-13906 [Klebsiella variicola]
ATGTGGGTCATCGAGACAACTGACACCTTTGATGAGTGGTTCGATGCACTGGATGATACCGATAGAGCCAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGTCCCATGCTGTCGAGACCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTGCGGGTCCAAAGCAAAGGAGATCCTATCAGGGCATTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGCGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT217549 WP_008499288.1 NZ_CP083853:c1112028-1111654 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT217549 NZ_CP114356:c13901-13599 [Klebsiella variicola]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References