Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 260764..261360 Replicon chromosome
Accession NZ_CP083853
Organism Enterobacter roggenkampii strain 12795-yvys

Toxin (Protein)


Gene name PumA Uniprot ID A0A0F1DED9
Locus tag LCD45_RS01190 Protein ID WP_023293553.1
Coordinates 261058..261360 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID W7P674
Locus tag LCD45_RS01185 Protein ID WP_021242718.1
Coordinates 260764..261051 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD45_RS01180 (LCD45_01185) 259136..260767 + 1632 WP_008503411.1 Na/Pi cotransporter family protein -
LCD45_RS01185 (LCD45_01190) 260764..261051 - 288 WP_021242718.1 putative addiction module antidote protein Antitoxin
LCD45_RS01190 (LCD45_01195) 261058..261360 - 303 WP_023293553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCD45_RS01195 (LCD45_01200) 261558..262430 + 873 WP_008503414.1 23S rRNA pseudouridine(2604) synthase RluF -
LCD45_RS01200 (LCD45_01205) 262431..262703 - 273 WP_014830263.1 DUF3811 domain-containing protein -
LCD45_RS01205 (LCD45_01210) 262754..263698 - 945 WP_023293551.1 ketopantoate/pantoate/pantothenate transporter PanS -
LCD45_RS01210 (LCD45_01215) 263804..265378 - 1575 WP_008503417.1 RNA repair transcriptional activator RtcR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11459.24 Da        Isoelectric Point: 10.1771

>T217546 WP_023293553.1 NZ_CP083853:c261360-261058 [Enterobacter roggenkampii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDVKPVGEGISELRIHFGPGYRIYFKDQGNYIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T217546 NZ_CP114354:c5455697-5455314 [Klebsiella variicola]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTAAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTGATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAACTACACCCTGAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10156.57 Da        Isoelectric Point: 6.4596

>AT217546 WP_021242718.1 NZ_CP083853:c261051-260764 [Enterobacter roggenkampii]
MHKLTPYDPANALVDDEEIAVFIADALETGDSTYIAKALGVVARAKGMSNISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGFGLTLKHAGD

Download         Length: 288 bp

>AT217546 NZ_CP114354:c5455939-5455697 [Klebsiella variicola]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F1DED9

Antitoxin

Source ID Structure
AlphaFold DB W7P674

References