Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 225591..226117 | Replicon | plasmid p14269_1 |
| Accession | NZ_CP083850 | ||
| Organism | Enterobacter hormaechei subsp. steigerwaltii strain 14269-yvys | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | LCD40_RS24815 | Protein ID | WP_000323025.1 |
| Coordinates | 225591..225878 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | LCD40_RS24820 | Protein ID | WP_000534858.1 |
| Coordinates | 225878..226117 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LCD40_RS24780 (LCD40_24810) | 221161..221337 | - | 177 | WP_001371930.1 | hypothetical protein | - |
| LCD40_RS24785 (LCD40_24815) | 221848..222792 | + | 945 | WP_000778029.1 | DUF5417 domain-containing protein | - |
| LCD40_RS24790 (LCD40_24820) | 222888..223490 | + | 603 | WP_001371889.1 | hypothetical protein | - |
| LCD40_RS24795 (LCD40_24825) | 223550..223900 | + | 351 | WP_000743059.1 | hypothetical protein | - |
| LCD40_RS24800 (LCD40_24830) | 223947..224150 | + | 204 | WP_001015183.1 | hypothetical protein | - |
| LCD40_RS24805 (LCD40_24835) | 224432..224752 | + | 321 | WP_000332796.1 | hypothetical protein | - |
| LCD40_RS24810 (LCD40_24840) | 225365..225490 | - | 126 | WP_229020258.1 | DUF5431 family protein | - |
| LCD40_RS24815 (LCD40_24850) | 225591..225878 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| LCD40_RS24820 (LCD40_24855) | 225878..226117 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| LCD40_RS24825 (LCD40_24860) | 226142..226246 | + | 105 | Protein_233 | protein YdfV | - |
| LCD40_RS24830 (LCD40_24865) | 226380..227303 | - | 924 | WP_000167917.1 | cation diffusion facilitator family transporter | - |
| LCD40_RS24835 (LCD40_24870) | 227503..228075 | - | 573 | WP_001515348.1 | cytochrome b/b6 domain-containing protein | - |
| LCD40_RS24840 (LCD40_24875) | 228551..229789 | - | 1239 | WP_000219087.1 | IS110-like element ISEsa2 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | ant(2'')-Ia / aadA2 / qacE / sul1 / qnrA1 / blaSHV-12 / catA1 / dfrA16 / blaCTX-M-9 / mcr-9 | - | 1..283626 | 283626 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T217544 WP_000323025.1 NZ_CP083850:c225878-225591 [Enterobacter hormaechei subsp. steigerwaltii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T217544 NZ_CP114354:4259123-4259341 [Klebsiella variicola]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT217544 WP_000534858.1 NZ_CP083850:c226117-225878 [Enterobacter hormaechei subsp. steigerwaltii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT217544 NZ_CP114354:4258722-4259096 [Klebsiella variicola]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCGCTTAATTATAAAATTAAGTACACTGAGGATAATAAACTGGTCGCTCAGGTTGACGAATATCTG
GACGATACTTTTACCTTGTTCAGTAACTACGGCATTAACTCAACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTCTCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCGCTTAATTATAAAATTAAGTACACTGAGGATAATAAACTGGTCGCTCAGGTTGACGAATATCTG
GACGATACTTTTACCTTGTTCAGTAACTACGGCATTAACTCAACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTCTCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|