Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4131660..4132317 Replicon chromosome
Accession NZ_CP083849
Organism Enterobacter hormaechei subsp. steigerwaltii strain 14269-yvys

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag LCD40_RS20015 Protein ID WP_017382887.1
Coordinates 4131907..4132317 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LCD40_RS20010 Protein ID WP_003863437.1
Coordinates 4131660..4131926 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD40_RS19990 (LCD40_20015) 4127066..4128499 - 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -
LCD40_RS19995 (LCD40_20020) 4128616..4129347 - 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
LCD40_RS20000 (LCD40_20025) 4129614..4130273 + 660 WP_003863433.1 hemolysin III family protein -
LCD40_RS20005 (LCD40_20030) 4130385..4131365 - 981 WP_022649306.1 tRNA-modifying protein YgfZ -
LCD40_RS20010 (LCD40_20035) 4131660..4131926 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LCD40_RS20015 (LCD40_20040) 4131907..4132317 + 411 WP_017382887.1 protein YgfX Toxin
LCD40_RS20020 (LCD40_20045) 4132319..4132840 - 522 WP_015571793.1 flavodoxin FldB -
LCD40_RS20025 (LCD40_20050) 4132942..4133838 + 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
LCD40_RS20030 (LCD40_20055) 4133867..4134580 + 714 WP_023304384.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LCD40_RS20035 (LCD40_20060) 4134586..4136319 + 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T217541 WP_017382887.1 NZ_CP083849:4131907-4132317 [Enterobacter hormaechei subsp. steigerwaltii]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T217541 NZ_CP114354:c1914444-1914112 [Klebsiella variicola]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCCGGTCACGAGCAAAGTGGAAAACGTCCGGTGCTTAT
CGTATCGAAAGCAGCGTTTAACAAGCAGACCCGGCTACCCGTTGTTGTACCCGTCACCAGCGGCGGAAACTTTGCCCGCG
CAACCGGTTTTACCGTCTCACTGGACGGCGTGGGAACAAAAACAACGGGCGTTCTTCGCTGCGACCAGCCAAGGACCATT
GTTATGGGAGCCCGGAGCGGTAAGCGGCTGGAACGCATACCTGATGCCGTTGTCAATGAGGTGCTTGCCAGGCTGGACGC
GATTCTCAGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT217541 WP_003863437.1 NZ_CP083849:4131660-4131926 [Enterobacter hormaechei subsp. steigerwaltii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT217541 NZ_CP114354:c1914663-1914445 [Klebsiella variicola]
ATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGGGCTGTCGACGGACAGCGAAGTGGGCATGACCATTGATAATGG
CTGTCTGATTATTGAACCTCAAAAACGTCCCCGCTATTCGCTCGAAGAACTGCTGGCGCAGTGTGATCCGCACGCTGAAA
TAAGCGAAGAGGGTCGGGAATGGATTGATGCGCCTGCGGTAGGCAAGGAGATCATGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References