Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 55908..56434 Replicon plasmid p16773_2
Accession NZ_CP083844
Organism Enterobacter asburiae strain 16773-yvys

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag LCD43_RS24705 Protein ID WP_000323025.1
Coordinates 56147..56434 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag LCD43_RS24700 Protein ID WP_000534858.1
Coordinates 55908..56147 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD43_RS24675 (LCD43_24695) 51334..52454 + 1121 WP_247952890.1 IS3-like element ISSen4 family transposase -
LCD43_RS24680 (LCD43_24700) 52483..53307 + 825 Protein_48 integrase core domain-containing protein -
LCD43_RS24685 (LCD43_24705) 53950..54522 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
LCD43_RS24690 (LCD43_24710) 54722..55645 + 924 WP_000167917.1 cation diffusion facilitator family transporter -
LCD43_RS24695 (LCD43_24715) 55779..55883 - 105 Protein_51 protein YdfV -
LCD43_RS24700 (LCD43_24720) 55908..56147 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
LCD43_RS24705 (LCD43_24725) 56147..56434 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
LCD43_RS24710 (LCD43_24735) 56506..56664 + 159 WP_008325141.1 type I toxin-antitoxin system Hok family toxin -
LCD43_RS24715 (LCD43_24740) 57541..57855 + 315 WP_045337198.1 hypothetical protein -
LCD43_RS24720 (LCD43_24745) 57965..58123 + 159 WP_223861909.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..98713 98713


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T217530 WP_000323025.1 NZ_CP083844:56147-56434 [Enterobacter asburiae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T217530 NZ_CP114332:4294745-4294963 [Klebsiella variicola]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT217530 WP_000534858.1 NZ_CP083844:55908-56147 [Enterobacter asburiae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT217530 NZ_CP114332:4294344-4294718 [Klebsiella variicola]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCGCTTAATTATAAAATTAAGTACACTGAGGATAATAAACTGGTCGCTCAGGTTGACGAATATCTG
GACGATACTTTTACCTTGTTCAGTAACTACGGCATTAACTCAACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTCTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References