Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4002670..4003456 Replicon chromosome
Accession NZ_CP083842
Organism Enterobacter asburiae strain 16773-yvys

Toxin (Protein)


Gene name yeeV Uniprot ID A0A097QYR4
Locus tag LCD43_RS19380 Protein ID WP_025799003.1
Coordinates 4002670..4003047 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A097QYU1
Locus tag LCD43_RS19385 Protein ID WP_025799001.1
Coordinates 4003097..4003456 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD43_RS19350 (LCD43_19375) 3997834..3999681 + 1848 WP_023309228.1 RNA polymerase sigma factor RpoD -
LCD43_RS19355 (LCD43_19380) 4000213..4000719 - 507 WP_045356107.1 G/U mismatch-specific DNA glycosylase -
LCD43_RS19365 (LCD43_19390) 4001023..4001868 - 846 WP_025799009.1 DUF4942 domain-containing protein -
LCD43_RS19370 (LCD43_19395) 4001950..4002153 - 204 WP_025799007.1 DUF957 domain-containing protein -
LCD43_RS19375 (LCD43_19400) 4002182..4002673 - 492 WP_045888216.1 DUF5983 family protein -
LCD43_RS19380 (LCD43_19405) 4002670..4003047 - 378 WP_025799003.1 TA system toxin CbtA family protein Toxin
LCD43_RS19385 (LCD43_19410) 4003097..4003456 - 360 WP_025799001.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LCD43_RS19390 (LCD43_19415) 4003480..4003701 - 222 WP_045888217.1 DUF987 domain-containing protein -
LCD43_RS19395 (LCD43_19420) 4003715..4004194 - 480 WP_025798999.1 DNA repair protein RadC -
LCD43_RS19400 (LCD43_19425) 4004206..4004637 - 432 WP_088903392.1 antirestriction protein -
LCD43_RS19405 (LCD43_19430) 4004860..4008012 - 3153 WP_045888218.1 autotransporter domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13993.97 Da        Isoelectric Point: 6.8515

>T217527 WP_025799003.1 NZ_CP083842:c4003047-4002670 [Enterobacter asburiae]
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR

Download         Length: 378 bp

>T217527 NZ_CP114332:2039500-2039602 [Klebsiella variicola]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13249.13 Da        Isoelectric Point: 6.9556

>AT217527 WP_025799001.1 NZ_CP083842:c4003456-4003097 [Enterobacter asburiae]
MSNKIPPVNHNIAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELN
PRHQHGVTLYAKGLTCNADTLGSCGYVYIAIYPTPATTE

Download         Length: 360 bp

>AT217527 NZ_CP114332:c2039608-2039464 [Klebsiella variicola]
ACCGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QYR4

Antitoxin

Source ID Structure
AlphaFold DB A0A097QYU1

References