Detailed information of TA system TA217526

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3796084..3796741
• Replicon: chromosome
• Accession: NZ_CP083842
• Organism: Enterobacter asburiae strain 16773-yvys

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LCD43_RS18355
• Protein ID: WP_045405042.1
• Coordinates: 3796084..3796494 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V3PWU7
• Locus tag: LCD43_RS18360
• Protein ID: WP_010435322.1
• Coordinates: 3796475..3796741 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCD43_RS18335 (LCD43_18350)	3792077..3793810	-	1734	WP_045355605.1	single-stranded-DNA-specific exonuclease RecJ	-
LCD43_RS18340 (LCD43_18355)	3793816..3794529	-	714	WP_045405046.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LCD43_RS18345 (LCD43_18360)	3794558..3795454	-	897	WP_023309098.1	site-specific tyrosine recombinase XerD	-
LCD43_RS18350 (LCD43_18365)	3795556..3796077	+	522	WP_045405044.1	flavodoxin FldB	-
LCD43_RS18355 (LCD43_18370)	3796084..3796494	-	411	WP_045405042.1	protein YgfX	Toxin
LCD43_RS18360 (LCD43_18375)	3796475..3796741	-	267	WP_010435322.1	FAD assembly factor SdhE	Antitoxin
LCD43_RS18365 (LCD43_18380)	3797036..3798016	+	981	WP_045405040.1	tRNA-modifying protein YgfZ	-
LCD43_RS18370 (LCD43_18385)	3798090..3798749	-	660	WP_023309101.1	hemolysin III family protein	-
LCD43_RS18375 (LCD43_18390)	3798915..3799226	-	312	WP_023309102.1	N(4)-acetylcytidine aminohydrolase	-
LCD43_RS18380 (LCD43_18395)	3799278..3800009	+	732	WP_032660101.1	MurR/RpiR family transcriptional regulator	-
LCD43_RS18385 (LCD43_18400)	3800126..3801559	+	1434	WP_045405037.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16157.12 Da
• Isoelectric Point: 10.9865

>T217526 WP_045405042.1 NZ_CP083842:c3796494-3796084 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNYGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Nucleotide

• Length: 411 bp

>T217526 NZ_CP114332:c1913244-1912912 [Klebsiella variicola]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCCGGTCACGAGCAAAGTGGAAAACGTCCGGTGCTTAT
CGTATCGAAAGCAGCGTTTAACAAGCAGACCCGGCTACCCGTTGTTGTACCCGTCACCAGCGGCGGAAACTTTGCCCGCG
CAACCGGTTTTACCGTCTCACTGGACGGCGTGGGAACAAAAACAACGGGCGTTCTTCGCTGCGACCAGCCAAGGACCATT
GTTATGGGAGCCCGGAGCGGTAAGCGGCTGGAACGCATACCTGATGCCGTTGTCAATGAGGTGCTTGCCAGGCTGGACGC
GATTCTCAGTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10555.02 Da
• Isoelectric Point: 5.1340

>AT217526 WP_010435322.1 NZ_CP083842:c3796741-3796475 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT217526 NZ_CP114332:c1913463-1913245 [Klebsiella variicola]
ATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGGGCTGTCGACGGACAGCGAAGTGGGCATGACCATTGATAATGG
CTGTCTGATTATTGAACCTCAAAAACGTCCCCGCTATTCGCTCGAAGAACTGCTGGCGCAGTGTGATCCGCACGCTGAAA
TAAGCGAAGAGGGTCGGGAATGGATTGATGCGCCTGCGGTAGGCAAGGAGATCATGTAG

Structures

Antitoxin

• AlphaFold DB: V3PWU7