Detailed information of TA system TA217514

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 475180..475696
• Replicon: chromosome
• Accession: NZ_CP083842
• Organism: Enterobacter asburiae strain 16773-yvys

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LCD43_RS02285
• Protein ID: WP_045402335.1
• Coordinates: 475412..475696 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V3EXX3
• Locus tag: LCD43_RS02280
• Protein ID: WP_008501400.1
• Coordinates: 475180..475422 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCD43_RS02265 (LCD43_02265)	471177..471917	+	741	WP_045355655.1	KDGP aldolase family protein	-
LCD43_RS02270 (LCD43_02270)	472033..473169	+	1137	WP_045402331.1	lactonase family protein	-
LCD43_RS02275 (LCD43_02275)	473192..475102	+	1911	WP_023310188.1	PRD domain-containing protein	-
LCD43_RS02280 (LCD43_02280)	475180..475422	+	243	WP_008501400.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LCD43_RS02285 (LCD43_02285)	475412..475696	+	285	WP_045402335.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LCD43_RS02290 (LCD43_02290)	475700..476164	-	465	WP_045402338.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LCD43_RS02295 (LCD43_02295)	476312..478450	-	2139	WP_045402340.1	anaerobic ribonucleoside-triphosphate reductase	-
LCD43_RS02300 (LCD43_02300)	478827..480470	-	1644	WP_045402342.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10907.73 Da
• Isoelectric Point: 10.3350

>T217514 WP_045402335.1 NZ_CP083842:475412-475696 [Enterobacter asburiae]
MTYELAFDPRALKEWSKLGQTVKDQFKKKLADVLVNPRVESARLHGLPDCYKIKLRTQGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T217514 NZ_CP114328:c4166430-4166113 [Klebsiella variicola]
ATATTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAAATAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTATGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8972.37 Da
• Isoelectric Point: 5.0651

>AT217514 WP_008501400.1 NZ_CP083842:475180-475422 [Enterobacter asburiae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT217514 NZ_CP114328:c4166120-4165833 [Klebsiella variicola]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCGTTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGTGGAATAAAGCACCCACAAATTTTACTTTACTAA

Structures

Antitoxin

• AlphaFold DB: V3EXX3