Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 308184..308734 | Replicon | plasmid pAR0468_1 |
| Accession | NZ_CP083835 | ||
| Organism | Enterobacter asburiae strain AR0468-yvys | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | S1EZ93 |
| Locus tag | LCD48_RS25705 | Protein ID | WP_007372286.1 |
| Coordinates | 308426..308734 (+) | Length | 103 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | S1FMC3 |
| Locus tag | LCD48_RS25700 | Protein ID | WP_007372285.1 |
| Coordinates | 308184..308423 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LCD48_RS25650 (LCD48_25650) | 303191..303586 | + | 396 | WP_024196081.1 | hypothetical protein | - |
| LCD48_RS25655 (LCD48_25655) | 303768..303959 | + | 192 | WP_016241560.1 | hypothetical protein | - |
| LCD48_RS25660 (LCD48_25660) | 304090..304785 | + | 696 | WP_007372278.1 | hypothetical protein | - |
| LCD48_RS25665 (LCD48_25665) | 304808..305005 | + | 198 | WP_032155220.1 | Lar family restriction alleviation protein | - |
| LCD48_RS25670 (LCD48_25670) | 305058..305516 | + | 459 | WP_008786599.1 | hypothetical protein | - |
| LCD48_RS25675 (LCD48_25675) | 305571..305804 | + | 234 | WP_008786598.1 | hypothetical protein | - |
| LCD48_RS25680 (LCD48_25680) | 305820..306452 | + | 633 | WP_007372282.1 | hypothetical protein | - |
| LCD48_RS25685 (LCD48_25685) | 306449..306859 | + | 411 | WP_016241559.1 | hypothetical protein | - |
| LCD48_RS25690 (LCD48_25690) | 306910..307584 | + | 675 | WP_008786597.1 | hypothetical protein | - |
| LCD48_RS25695 (LCD48_25695) | 307581..308045 | + | 465 | WP_246862875.1 | hypothetical protein | - |
| LCD48_RS25700 (LCD48_25700) | 308184..308423 | + | 240 | WP_007372285.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| LCD48_RS25705 (LCD48_25705) | 308426..308734 | + | 309 | WP_007372286.1 | CcdB family protein | Toxin |
| LCD48_RS25710 (LCD48_25710) | 308755..308940 | + | 186 | WP_246917672.1 | hypothetical protein | - |
| LCD48_RS25715 (LCD48_25715) | 309068..309622 | + | 555 | WP_007372288.1 | hypothetical protein | - |
| LCD48_RS25720 (LCD48_25720) | 309692..310309 | + | 618 | WP_007372289.1 | hypothetical protein | - |
| LCD48_RS25725 (LCD48_25725) | 310392..310862 | + | 471 | WP_007372290.1 | HAD domain-containing protein | - |
| LCD48_RS25730 (LCD48_25730) | 311131..311451 | + | 321 | WP_233269684.1 | hypothetical protein | - |
| LCD48_RS25735 (LCD48_25735) | 311462..311860 | + | 399 | WP_007372292.1 | hypothetical protein | - |
| LCD48_RS25740 (LCD48_25740) | 311944..312270 | + | 327 | WP_007372293.1 | hypothetical protein | - |
| LCD48_RS25745 (LCD48_25745) | 312322..312537 | + | 216 | WP_139156956.1 | hypothetical protein | - |
| LCD48_RS25750 (LCD48_25750) | 312633..312971 | - | 339 | WP_007372294.1 | hypothetical protein | - |
| LCD48_RS25755 (LCD48_25755) | 313209..313652 | + | 444 | WP_007372295.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..373441 | 373441 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11351.17 Da Isoelectric Point: 8.5044
>T217511 WP_007372286.1 NZ_CP083835:308426-308734 [Enterobacter asburiae]
MQYTVYRNPGNSQAYPYLLDIQSDIIGELNTRLVIPLHRLKKGASAPVARLTPVIQVEGNDVILMTHEMASVRVKQLGQA
VMDASPFRHTIKSAVDFLLDGF
MQYTVYRNPGNSQAYPYLLDIQSDIIGELNTRLVIPLHRLKKGASAPVARLTPVIQVEGNDVILMTHEMASVRVKQLGQA
VMDASPFRHTIKSAVDFLLDGF
Download Length: 309 bp
>T217511 NZ_CP114328:c1914444-1914112 [Klebsiella variicola]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCCGGTCACGAGCAAAGTGGAAAACGTCCGGTGCTTAT
CGTATCGAAAGCAGCGTTTAACAAGCAGACCCGGCTACCCGTTGTTGTACCCGTCACCAGCGGCGGAAACTTTGCCCGCG
CAACCGGTTTTACCGTCTCACTGGACGGCGTGGGAACAAAAACAACGGGCGTTCTTCGCTGCGACCAGCCAAGGACCATT
GTTATGGGAGCCCGGAGCGGTAAGCGGCTGGAACGCATACCTGATGCCGTTGTCAATGAGGTGCTTGCCAGGCTGGACGC
GATTCTCAGTTAA
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCCGGTCACGAGCAAAGTGGAAAACGTCCGGTGCTTAT
CGTATCGAAAGCAGCGTTTAACAAGCAGACCCGGCTACCCGTTGTTGTACCCGTCACCAGCGGCGGAAACTTTGCCCGCG
CAACCGGTTTTACCGTCTCACTGGACGGCGTGGGAACAAAAACAACGGGCGTTCTTCGCTGCGACCAGCCAAGGACCATT
GTTATGGGAGCCCGGAGCGGTAAGCGGCTGGAACGCATACCTGATGCCGTTGTCAATGAGGTGCTTGCCAGGCTGGACGC
GATTCTCAGTTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8784.97 Da Isoelectric Point: 8.6387
>AT217511 WP_007372285.1 NZ_CP083835:308184-308423 [Enterobacter asburiae]
MQATAARQKKTVSVTLEPMLVQQAKDAGINLSATLAEALQSKLKASAAEEWKRQNRAGIQELNRITEEHGLLSDEYRTF
MQATAARQKKTVSVTLEPMLVQQAKDAGINLSATLAEALQSKLKASAAEEWKRQNRAGIQELNRITEEHGLLSDEYRTF
Download Length: 240 bp
>AT217511 NZ_CP114328:c1914663-1914445 [Klebsiella variicola]
ATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGGGCTGTCGACGGACAGCGAAGTGGGCATGACCATTGATAATGG
CTGTCTGATTATTGAACCTCAAAAACGTCCCCGCTATTCGCTCGAAGAACTGCTGGCGCAGTGTGATCCGCACGCTGAAA
TAAGCGAAGAGGGTCGGGAATGGATTGATGCGCCTGCGGTAGGCAAGGAGATCATGTAG
ATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGGGCTGTCGACGGACAGCGAAGTGGGCATGACCATTGATAATGG
CTGTCTGATTATTGAACCTCAAAAACGTCCCCGCTATTCGCTCGAAGAACTGCTGGCGCAGTGTGATCCGCACGCTGAAA
TAAGCGAAGAGGGTCGGGAATGGATTGATGCGCCTGCGGTAGGCAAGGAGATCATGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|