Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 148479..149265 | Replicon | plasmid pAR0468_1 |
| Accession | NZ_CP083835 | ||
| Organism | Enterobacter asburiae strain AR0468-yvys | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A097QYR4 |
| Locus tag | LCD48_RS24900 | Protein ID | WP_025799003.1 |
| Coordinates | 148479..148856 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A097QYU1 |
| Locus tag | LCD48_RS24905 | Protein ID | WP_025799001.1 |
| Coordinates | 148906..149265 (-) | Length | 120 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LCD48_RS24870 (LCD48_24875) | 144896..145858 | + | 963 | WP_007372199.1 | plasmid segregation protein ParM | - |
| LCD48_RS24875 (LCD48_24880) | 145872..146258 | + | 387 | WP_009652914.1 | plasmid partitioning/stability family protein | - |
| LCD48_RS24880 (LCD48_24885) | 146285..146689 | - | 405 | WP_007372197.1 | FCD domain-containing protein | - |
| LCD48_RS24885 (LCD48_24890) | 146832..147677 | - | 846 | WP_025799009.1 | DUF4942 domain-containing protein | - |
| LCD48_RS24890 (LCD48_24895) | 147759..147962 | - | 204 | WP_025799007.1 | DUF957 domain-containing protein | - |
| LCD48_RS24895 (LCD48_24900) | 147991..148482 | - | 492 | WP_045888216.1 | DUF5983 family protein | - |
| LCD48_RS24900 (LCD48_24905) | 148479..148856 | - | 378 | WP_025799003.1 | TA system toxin CbtA family protein | Toxin |
| LCD48_RS24905 (LCD48_24910) | 148906..149265 | - | 360 | WP_025799001.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LCD48_RS24910 (LCD48_24915) | 149289..149510 | - | 222 | WP_045888217.1 | DUF987 domain-containing protein | - |
| LCD48_RS24915 (LCD48_24920) | 149524..149595 | - | 72 | Protein_191 | hypothetical protein | - |
| LCD48_RS24920 (LCD48_24925) | 150119..151270 | - | 1152 | Protein_192 | trypsin-like peptidase domain-containing protein | - |
| LCD48_RS24925 (LCD48_24930) | 151290..152252 | - | 963 | WP_021567591.1 | zinc metalloprotease HtpX | - |
| LCD48_RS24930 (LCD48_24935) | 152239..152727 | - | 489 | WP_032731988.1 | phosphate-starvation-inducible PsiE family protein | - |
| LCD48_RS24935 | 152739..152981 | - | 243 | WP_001446206.1 | diguanylate cyclase | - |
| LCD48_RS24940 (LCD48_24940) | 152872..153588 | - | 717 | WP_127472360.1 | sensor domain-containing diguanylate cyclase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..373441 | 373441 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13993.97 Da Isoelectric Point: 6.8515
>T217510 WP_025799003.1 NZ_CP083835:c148856-148479 [Enterobacter asburiae]
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR
Download Length: 378 bp
>T217510 NZ_CP114328:1911763-1912095 [Klebsiella variicola]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTCCTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACTCGGCTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGCTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGAACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGCCGTTGTCAATGAAGTGCTTGCCAGGCTGGACGC
GATTCTCAGTTAA
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTCCTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACTCGGCTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGCTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGAACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGCCGTTGTCAATGAAGTGCTTGCCAGGCTGGACGC
GATTCTCAGTTAA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13249.13 Da Isoelectric Point: 6.9556
>AT217510 WP_025799001.1 NZ_CP083835:c149265-148906 [Enterobacter asburiae]
MSNKIPPVNHNIAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELN
PRHQHGVTLYAKGLTCNADTLGSCGYVYIAIYPTPATTE
MSNKIPPVNHNIAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELN
PRHQHGVTLYAKGLTCNADTLGSCGYVYIAIYPTPATTE
Download Length: 360 bp
>AT217510 NZ_CP114328:1911505-1911762 [Klebsiella variicola]
ATGTACAAAACTCGCCTGAAAAAGGTTGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAGCGCTGGAGCT
GTCGACAGACAGCGAAGTGGGTATGACTATAGATAATGGCTGCCTGATTATTGAACCGCAGAAACGGCCCCATTATTCGC
TTGAGGAACTGTTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA
ATGTACAAAACTCGCCTGAAAAAGGTTGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAGCGCTGGAGCT
GTCGACAGACAGCGAAGTGGGTATGACTATAGATAATGGCTGCCTGATTATTGAACCGCAGAAACGGCCCCATTATTCGC
TTGAGGAACTGTTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A097QYR4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A097QYU1 |