Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4173433..4174219 Replicon chromosome
Accession NZ_CP083834
Organism Enterobacter asburiae strain AR0468-yvys

Toxin (Protein)


Gene name yeeV Uniprot ID A0A097QYR4
Locus tag LCD48_RS20425 Protein ID WP_025799003.1
Coordinates 4173433..4173810 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A097QYU1
Locus tag LCD48_RS20430 Protein ID WP_025799001.1
Coordinates 4173860..4174219 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD48_RS20395 (LCD48_20395) 4169026..4170873 + 1848 WP_023309228.1 RNA polymerase sigma factor RpoD -
LCD48_RS20400 (LCD48_20400) 4170976..4171482 - 507 WP_029741755.1 G/U mismatch-specific DNA glycosylase -
LCD48_RS20410 (LCD48_20410) 4171786..4172631 - 846 WP_025799009.1 DUF4942 domain-containing protein -
LCD48_RS20415 (LCD48_20415) 4172713..4172916 - 204 WP_025799007.1 DUF957 domain-containing protein -
LCD48_RS20420 (LCD48_20420) 4172945..4173436 - 492 WP_045888216.1 DUF5983 family protein -
LCD48_RS20425 (LCD48_20425) 4173433..4173810 - 378 WP_025799003.1 TA system toxin CbtA family protein Toxin
LCD48_RS20430 (LCD48_20430) 4173860..4174219 - 360 WP_025799001.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LCD48_RS20435 (LCD48_20435) 4174243..4174464 - 222 WP_045888217.1 DUF987 domain-containing protein -
LCD48_RS20440 (LCD48_20440) 4174478..4174957 - 480 WP_025798999.1 DNA repair protein RadC -
LCD48_RS20445 (LCD48_20445) 4174969..4175400 - 432 WP_088903392.1 antirestriction protein -
LCD48_RS20450 (LCD48_20450) 4175623..4178775 - 3153 WP_045888218.1 autotransporter domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13993.97 Da        Isoelectric Point: 6.8515

>T217508 WP_025799003.1 NZ_CP083834:c4173810-4173433 [Enterobacter asburiae]
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR

Download         Length: 378 bp

>T217508 NZ_CP114328:368555-368902 [Klebsiella variicola]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGGTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGAGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGACGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13249.13 Da        Isoelectric Point: 6.9556

>AT217508 WP_025799001.1 NZ_CP083834:c4174219-4173860 [Enterobacter asburiae]
MSNKIPPVNHNIAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELN
PRHQHGVTLYAKGLTCNADTLGSCGYVYIAIYPTPATTE

Download         Length: 360 bp

>AT217508 NZ_CP114328:368902-369201 [Klebsiella variicola]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGATCCGCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACGTTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QYR4

Antitoxin

Source ID Structure
AlphaFold DB A0A097QYU1

References