Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3939602..3940259 Replicon chromosome
Accession NZ_CP083834
Organism Enterobacter asburiae strain AR0468-yvys

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag LCD48_RS19225 Protein ID WP_021242050.1
Coordinates 3939602..3940012 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag LCD48_RS19230 Protein ID WP_010435322.1
Coordinates 3939993..3940259 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD48_RS19205 (LCD48_19205) 3935595..3937328 - 1734 WP_246916918.1 single-stranded-DNA-specific exonuclease RecJ -
LCD48_RS19210 (LCD48_19210) 3937334..3938047 - 714 WP_023309097.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LCD48_RS19215 (LCD48_19215) 3938076..3938972 - 897 WP_039262980.1 site-specific tyrosine recombinase XerD -
LCD48_RS19220 (LCD48_19220) 3939074..3939595 + 522 WP_039262979.1 flavodoxin FldB -
LCD48_RS19225 (LCD48_19225) 3939602..3940012 - 411 WP_021242050.1 protein YgfX Toxin
LCD48_RS19230 (LCD48_19230) 3939993..3940259 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
LCD48_RS19235 (LCD48_19235) 3940554..3941534 + 981 WP_045888315.1 tRNA-modifying protein YgfZ -
LCD48_RS19240 (LCD48_19240) 3941604..3942257 - 654 WP_045888316.1 hemolysin III family protein -
LCD48_RS19245 (LCD48_19245) 3942423..3942734 - 312 WP_045888317.1 N(4)-acetylcytidine aminohydrolase -
LCD48_RS19250 (LCD48_19250) 3942786..3943517 + 732 WP_032660101.1 MurR/RpiR family transcriptional regulator -
LCD48_RS19255 (LCD48_19255) 3943634..3945067 + 1434 WP_033146593.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T217507 WP_021242050.1 NZ_CP083834:c3940012-3939602 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T217507 NZ_CP114328:342415-342783 [Klebsiella variicola]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGACGTTGCCGG
TATGCCCGACCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCACCTGCTGGTGATTTCTCGCGGCCATATTTTCAATGATGGAAATAAGCGTACGGCACTGTTT
ATTACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCGGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCGGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT217507 WP_010435322.1 NZ_CP083834:c3940259-3939993 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT217507 NZ_CP114328:342197-342418 [Klebsiella variicola]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCGGTCATCATCAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATTATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References