Detailed information of TA system TA217505

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3698194..3698872
• Replicon: chromosome
• Accession: NZ_CP083834
• Organism: Enterobacter asburiae strain AR0468-yvys

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: LCD48_RS18115
• Protein ID: WP_151887033.1
• Coordinates: 3698549..3698872 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: LCD48_RS18110
• Protein ID: WP_151887032.1
• Coordinates: 3698194..3698517 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCD48_RS18075 (LCD48_18075)	3693615..3694313	+	699	WP_151887027.1	WYL domain-containing protein	-
LCD48_RS18080 (LCD48_18080)	3694310..3694747	+	438	WP_151887028.1	hypothetical protein	-
LCD48_RS18085 (LCD48_18085)	3694783..3695145	+	363	WP_151887029.1	hypothetical protein	-
LCD48_RS18090 (LCD48_18090)	3695533..3696201	-	669	WP_226777967.1	hypothetical protein	-
LCD48_RS18095 (LCD48_18095)	3696621..3697439	+	819	WP_192938245.1	DUF932 domain-containing protein	-
LCD48_RS18100 (LCD48_18100)	3697472..3697942	+	471	WP_151887031.1	DNA repair protein RadC	-
LCD48_RS18105 (LCD48_18105)	3697951..3698172	+	222	WP_032642916.1	DUF987 domain-containing protein	-
LCD48_RS18110 (LCD48_18110)	3698194..3698517	+	324	WP_151887032.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
LCD48_RS18115 (LCD48_18115)	3698549..3698872	+	324	WP_151887033.1	TA system toxin CbtA family protein	Toxin
LCD48_RS18120 (LCD48_18120)	3699589..3699945	+	357	WP_029740047.1	hypothetical protein	-
LCD48_RS18125 (LCD48_18125)	3700119..3700676	+	558	WP_045888783.1	YceI family protein	-
LCD48_RS18130 (LCD48_18130)	3700668..3701459	-	792	WP_045888784.1	membrane protein	-
LCD48_RS18135 (LCD48_18135)	3701456..3701986	-	531	WP_080338169.1	sigma-70 family RNA polymerase sigma factor	-
LCD48_RS18140 (LCD48_18140)	3701994..3702521	-	528	WP_033146334.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-106)

Antitoxin

• Antitoxin CbeA (4-101)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12079.90 Da
• Isoelectric Point: 6.3228

>T217505 WP_151887033.1 NZ_CP083834:3698549-3698872 [Enterobacter asburiae]
MHIASVPATVPVSSRLSPVQVWQQLLAYLLEHHYGLALNDTPFHDDATIQEHIEAGITLADAVNFLVEKYELVRIDRKGF
SWQEQTPFITAMDILRAKKSIGLLPRS

Nucleotide

• Length: 324 bp

>T217505 NZ_CP114326:c14256-13906 [Klebsiella variicola]
ATGTGGGTCATCGAGACAACTGACACCTTTGATGAGTGGTTCGATGCACTGGATGATACCGATAGAGCCAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGTCCCATGCTGTCGAGACCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTGCGGGTCCAAAGCAAAGGAGATCCTATCAGGGCATTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGCGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11986.65 Da
• Isoelectric Point: 6.7389

>AT217505 WP_151887032.1 NZ_CP083834:3698194-3698517 [Enterobacter asburiae]
MQNSWGLKRDISPCFGARLVQEGCRLHFLADRAGISGTFNEEEALRLDQAFPLVMKQLELMLTTGELNPRHQHCVTLHHN
GLTCEADTLGSHGYVYIVIYSQASATR

Nucleotide

• Length: 324 bp

>AT217505 NZ_CP114326:c13901-13599 [Klebsiella variicola]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA