Detailed information of TA system TA217492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 521462..521978
• Replicon: chromosome
• Accession: NZ_CP083834
• Organism: Enterobacter asburiae strain AR0468-yvys

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LCD48_RS02505
• Protein ID: WP_045888484.1
• Coordinates: 521694..521978 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V3EXX3
• Locus tag: LCD48_RS02500
• Protein ID: WP_008501400.1
• Coordinates: 521462..521704 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCD48_RS02485 (LCD48_02480)	517463..518203	+	741	WP_045888481.1	KDGP aldolase family protein	-
LCD48_RS02490 (LCD48_02485)	518318..519454	+	1137	WP_045888482.1	lactonase family protein	-
LCD48_RS02495 (LCD48_02490)	519474..521384	+	1911	WP_045888483.1	PRD domain-containing protein	-
LCD48_RS02500 (LCD48_02495)	521462..521704	+	243	WP_008501400.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LCD48_RS02505 (LCD48_02500)	521694..521978	+	285	WP_045888484.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LCD48_RS02510 (LCD48_02505)	521982..522446	-	465	WP_039261072.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LCD48_RS02515 (LCD48_02510)	522575..524713	-	2139	WP_045888490.1	anaerobic ribonucleoside-triphosphate reductase	-
LCD48_RS02520 (LCD48_02515)	525090..526733	-	1644	WP_045888485.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10878.73 Da
• Isoelectric Point: 10.3350

>T217492 WP_045888484.1 NZ_CP083834:521694-521978 [Enterobacter asburiae]
MIYELAFDPRALKEWSKLGQTVKDQFKKKLADVLVSPRVESARLHGLPDCYKIKLRSQGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T217492 NZ_CP114324:342415-342783 [Klebsiella variicola]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGACGTTGCCGG
TATGCCCGACCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCACCTGCTGGTGATTTCTCGCGGCCATATTTTCAATGATGGAAATAAGCGTACGGCACTGTTT
ATTACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCGGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCGGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8972.37 Da
• Isoelectric Point: 5.0651

>AT217492 WP_008501400.1 NZ_CP083834:521462-521704 [Enterobacter asburiae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT217492 NZ_CP114324:342197-342418 [Klebsiella variicola]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCGGTCATCATCAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATTATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: V3EXX3