Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 4561774..4562390 Replicon chromosome
Accession NZ_CP083828
Organism Enterobacter kobei strain 11778-yvys

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LCD42_RS21655 Protein ID WP_176261116.1
Coordinates 4561774..4562145 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LCD42_RS21660 Protein ID WP_047343711.1
Coordinates 4562148..4562390 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD42_RS21640 (LCD42_21685) 4559274..4560176 + 903 WP_008501831.1 formate dehydrogenase subunit beta -
LCD42_RS21645 (LCD42_21690) 4560173..4560808 + 636 WP_008501832.1 formate dehydrogenase cytochrome b556 subunit -
LCD42_RS21650 (LCD42_21695) 4560805..4561734 + 930 WP_176261117.1 formate dehydrogenase accessory protein FdhE -
LCD42_RS21655 (LCD42_21700) 4561774..4562145 - 372 WP_176261116.1 type II toxin-antitoxin system VapC family toxin Toxin
LCD42_RS21660 (LCD42_21705) 4562148..4562390 - 243 WP_047343711.1 ribbon-helix-helix protein, CopG family Antitoxin
LCD42_RS21665 (LCD42_21710) 4562590..4563510 + 921 WP_176261115.1 alpha/beta hydrolase -
LCD42_RS21670 (LCD42_21715) 4563519..4564460 - 942 WP_023331628.1 fatty acid biosynthesis protein FabY -
LCD42_RS21675 (LCD42_21720) 4564505..4564942 - 438 WP_014885747.1 D-aminoacyl-tRNA deacylase -
LCD42_RS21680 (LCD42_21725) 4564939..4565820 - 882 WP_047343713.1 virulence factor BrkB family protein -
LCD42_RS21685 (LCD42_21730) 4565814..4566413 - 600 WP_023331629.1 glucose-1-phosphatase -
LCD42_RS21690 (LCD42_21735) 4566533..4567333 - 801 WP_014885750.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13726.94 Da        Isoelectric Point: 6.6410

>T217471 WP_176261116.1 NZ_CP083828:c4562145-4561774 [Enterobacter kobei]
MEHMAVFDTNILIDLFNNRVEAADAIDRTASHRAISLITWMEVMVGARKHGHEVKTAAVMGAFEIIDVTREIAERSVLLR
EKHGMKLPDAIILATAQSRNCPLISRNTKDFAGIDQVVTPYLL

Download         Length: 372 bp

>T217471 NZ_CP114316:c5168722-5167805 [Klebsiella variicola]
ATGGATATACAGGCGCCCTATTATCGGCAGGTTGCTCTGTTAATGCAGGTTTTACCCTATGTTGCCGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACGGCAATCAATCTCTTTATCCGTGATTTCCCACGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAACGATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCTAATCTGCAACAACAG
GCAGGTATAAACGCTGTATTACAAGCTAATCGTTCCGATGAGATGCGTGTCGTTGTTACTACCGATAGCGCACAAATAAA
GATAGAGGTCTCACCGGTCGCACGGGGAACATTATATCCACCACAGGAGCGAGAGGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCGGTGGTTTCGTTGCCCGATCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGATGTGAAATTACTTCTTGATGCGCAGGAGCTTAACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTTAGCCATAATCGGCCTCTGGCTGAAGTGCTTAGTCCTCGCTGGAAAGATATTGCTGAACCCTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCTACAGGATGATTGATGCGTTAAAATCC
TGTTTCACGCAACAGGATATCGATTTTTTGCTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAACACG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGTTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9469.72 Da        Isoelectric Point: 4.3962

>AT217471 WP_047343711.1 NZ_CP083828:c4562390-4562148 [Enterobacter kobei]
MSLLADLDMGRILIDLSDDVIQRLDKLKQLRNRPRAELLREAIEQYLDQQSSSVIRDALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT217471 NZ_CP114316:c5169486-5168728 [Klebsiella variicola]
ATGTCATCAAAATTAAACTGGCTGCTGCAAAACAGTGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCGGCATGC
CATCTCTCCCTCTCAGGCCTTTAAATACACGCAAAGTGGCTGGTTAAAAAAACGAGGCAACGGCGTATACGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTAGCCGCTCCGGTGTATGTCGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGTCGTTCACACTATCTACAGCTCAAACAAAACCAGTGCTGGTTGAGTATGGAAAATAAAGCGCT
GCTGCCAAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGCAAAAACTGCCGGTGCTGGATGATA
AATACCGCGTAACGCTTGATGTAAAAGGGAAAAGACTCACCGGCAGTGCGCCGGAACTGGCTGCTTACGAGTTGTTGAGC
GCGGTACCGGGGACCCTCTCATTTAACCACGCGGCAGAGCTTTTCCAGGGACTAGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTGCTTTCTGTCAGCCAGTCCGTGCAGACCAAGCGTTTGTATCTCTTTTTCGCCAGTTTTTACGAGCATGGTTGGC
TCAGACGAATCGATAGCCAAAAAATCGATCTGGGTGCGGGTAAGCGGCAAATCGTGGTAAATGGCAAGTTCAATGCTCAA
TATCAAATCACTGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References