Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3786021..3786678 Replicon chromosome
Accession NZ_CP083828
Organism Enterobacter kobei strain 11778-yvys

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag LCD42_RS17895 Protein ID WP_014885136.1
Coordinates 3786021..3786431 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag LCD42_RS17900 Protein ID WP_010435322.1
Coordinates 3786412..3786678 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD42_RS17875 (LCD42_17910) 3782015..3783748 - 1734 WP_032635612.1 single-stranded-DNA-specific exonuclease RecJ -
LCD42_RS17880 (LCD42_17915) 3783754..3784467 - 714 WP_045134112.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LCD42_RS17885 (LCD42_17920) 3784496..3785392 - 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
LCD42_RS17890 (LCD42_17925) 3785494..3786015 + 522 WP_014885135.1 flavodoxin FldB -
LCD42_RS17895 (LCD42_17930) 3786021..3786431 - 411 WP_014885136.1 protein YgfX Toxin
LCD42_RS17900 (LCD42_17935) 3786412..3786678 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
LCD42_RS17905 (LCD42_17940) 3786973..3787953 + 981 WP_014885137.1 tRNA-modifying protein YgfZ -
LCD42_RS17910 (LCD42_17945) 3788038..3788697 - 660 WP_023331242.1 hemolysin III family protein -
LCD42_RS17915 (LCD42_17950) 3788963..3789694 + 732 WP_014885139.1 MurR/RpiR family transcriptional regulator -
LCD42_RS17920 (LCD42_17955) 3789811..3791244 + 1434 WP_014885140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T217470 WP_014885136.1 NZ_CP083828:c3786431-3786021 [Enterobacter kobei]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T217470 NZ_CP114316:4294739-4294957 [Klebsiella variicola]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT217470 WP_010435322.1 NZ_CP083828:c3786678-3786412 [Enterobacter kobei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT217470 NZ_CP114316:4294338-4294712 [Klebsiella variicola]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCGCTTAATTATAAAATTAAGTACACTGAGGATAATAAACTGGTCGCTCAGGTTGACGAATATCTG
GACGATACTTTTACCTTGTTCAGTAACTACGGCATTAACTCAACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTCTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References