Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3798090..3798750 Replicon chromosome
Accession NZ_CP083821
Organism Enterobacter cloacae subsp. cloacae strain 12961-yvys

Toxin (Protein)


Gene name cptA Uniprot ID A0A5E1AGQ2
Locus tag LCD47_RS18140 Protein ID WP_023620447.1
Coordinates 3798090..3798503 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A5E1AG01
Locus tag LCD47_RS18145 Protein ID WP_013098615.1
Coordinates 3798484..3798750 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD47_RS18120 (LCD47_18145) 3794083..3795816 - 1734 WP_057071755.1 single-stranded-DNA-specific exonuclease RecJ -
LCD47_RS18125 (LCD47_18150) 3795822..3796535 - 714 WP_013098611.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LCD47_RS18130 (LCD47_18155) 3796564..3797460 - 897 WP_013098612.1 site-specific tyrosine recombinase XerD -
LCD47_RS18135 (LCD47_18160) 3797562..3798083 + 522 WP_013098613.1 flavodoxin FldB -
LCD47_RS18140 (LCD47_18165) 3798090..3798503 - 414 WP_023620447.1 protein YgfX Toxin
LCD47_RS18145 (LCD47_18170) 3798484..3798750 - 267 WP_013098615.1 FAD assembly factor SdhE Antitoxin
LCD47_RS18150 (LCD47_18175) 3799045..3800025 + 981 WP_023620448.1 tRNA-modifying protein YgfZ -
LCD47_RS18155 (LCD47_18180) 3800135..3800794 - 660 WP_003863433.1 hemolysin III family protein -
LCD47_RS18160 (LCD47_18185) 3801060..3801791 + 732 WP_058683450.1 MurR/RpiR family transcriptional regulator -
LCD47_RS18165 (LCD47_18190) 3801908..3803341 + 1434 WP_191979754.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16220.21 Da        Isoelectric Point: 10.9554

>T217458 WP_023620447.1 NZ_CP083821:c3798503-3798090 [Enterobacter cloacae subsp. cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLSSGMMLRLRQVGGGKCQHLWLAADSMDIAEWRELRRMLLQQQPTQE

Download         Length: 414 bp

>T217458 NZ_CP114313:7596-8012 [Klebsiella variicola]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1456

>AT217458 WP_013098615.1 NZ_CP083821:c3798750-3798484 [Enterobacter cloacae subsp. cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDEDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT217458 NZ_CP114313:7369-7599 [Klebsiella variicola]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AGQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AG01

References