Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA(toxin) |
| Location | 3092786..3094569 | Replicon | chromosome |
| Accession | NZ_CP083821 | ||
| Organism | Enterobacter cloacae subsp. cloacae strain 12961-yvys | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | LCD47_RS14740 | Protein ID | WP_139936162.1 |
| Coordinates | 3092786..3094135 (+) | Length | 450 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | LCD47_RS14745 | Protein ID | WP_029883072.1 |
| Coordinates | 3094132..3094569 (+) | Length | 146 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LCD47_RS14715 (LCD47_14740) | 3088606..3089538 | - | 933 | WP_191979508.1 | tRNA dihydrouridine(16) synthase DusC | - |
| LCD47_RS14720 (LCD47_14745) | 3089706..3090104 | + | 399 | WP_023619766.1 | CidA/LrgA family protein | - |
| LCD47_RS14725 (LCD47_14750) | 3090101..3090796 | + | 696 | WP_139936165.1 | CidB/LrgB family autolysis modulator | - |
| LCD47_RS14730 (LCD47_14755) | 3090926..3091810 | + | 885 | WP_139936164.1 | cytidine deaminase | - |
| LCD47_RS14735 (LCD47_14760) | 3091938..3092651 | + | 714 | WP_023619764.1 | outer membrane permeability protein SanA | - |
| LCD47_RS14740 (LCD47_14765) | 3092786..3094135 | + | 1350 | WP_139936162.1 | HipA domain-containing protein | Toxin |
| LCD47_RS14745 (LCD47_14770) | 3094132..3094569 | + | 438 | WP_029883072.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| LCD47_RS14750 (LCD47_14775) | 3094621..3095631 | - | 1011 | WP_013097952.1 | galactose/methyl galactoside ABC transporter permease MglC | - |
| LCD47_RS14755 (LCD47_14780) | 3095647..3097167 | - | 1521 | WP_029883073.1 | galactose/methyl galactoside ABC transporter ATP-binding protein MglA | - |
| LCD47_RS14760 (LCD47_14785) | 3097248..3098246 | - | 999 | WP_014832691.1 | galactose/glucose ABC transporter substrate-binding protein MglB | - |
| LCD47_RS14765 (LCD47_14790) | 3098542..3099564 | - | 1023 | WP_058680889.1 | HTH-type transcriptional regulator GalS | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 450 a.a. Molecular weight: 51149.69 Da Isoelectric Point: 4.5348
>T217455 WP_139936162.1 NZ_CP083821:3092786-3094135 [Enterobacter cloacae subsp. cloacae]
METLTVQAYLNETWTDIALIKYPGSENNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDQGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNEFARTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVDTMR
LEEGSHYPSLWLPRFDIVRNEQDQLIRLGMESVYSLLQKAPGTLLDHEATLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENHIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNAIAQALAEWIPPTT
LLDALHDTAVQLIELPERLEARGVPDQIMEMPAIGFRYIPNKLSRWGLL
METLTVQAYLNETWTDIALIKYPGSENNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDQGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNEFARTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVDTMR
LEEGSHYPSLWLPRFDIVRNEQDQLIRLGMESVYSLLQKAPGTLLDHEATLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENHIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNAIAQALAEWIPPTT
LLDALHDTAVQLIELPERLEARGVPDQIMEMPAIGFRYIPNKLSRWGLL
Download Length: 1350 bp
>T217455 NZ_CP114312:4294745-4294963 [Klebsiella variicola]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA
Antitoxin
Download Length: 146 a.a. Molecular weight: 16218.68 Da Isoelectric Point: 10.6347
>AT217455 WP_029883072.1 NZ_CP083821:3094132-3094569 [Enterobacter cloacae subsp. cloacae]
MKISNKSESELLQTLARVRSVNEKRRHDEDEDPDKSSVVKRQRVSSGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGMKQDEYAKLVSVSRKTLSDVENGRGNYSADIINKIFKPFGLQTGLVPISKSLIASLFT
MKISNKSESELLQTLARVRSVNEKRRHDEDEDPDKSSVVKRQRVSSGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGMKQDEYAKLVSVSRKTLSDVENGRGNYSADIINKIFKPFGLQTGLVPISKSLIASLFT
Download Length: 438 bp
>AT217455 NZ_CP114312:4294344-4294718 [Klebsiella variicola]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCGCTTAATTATAAAATTAAGTACACTGAGGATAATAAACTGGTCGCTCAGGTTGACGAATATCTG
GACGATACTTTTACCTTGTTCAGTAACTACGGCATTAACTCAACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTCTCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCGCTTAATTATAAAATTAAGTACACTGAGGATAATAAACTGGTCGCTCAGGTTGACGAATATCTG
GACGATACTTTTACCTTGTTCAGTAACTACGGCATTAACTCAACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTCTCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|