Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 542856..543372 | Replicon | chromosome |
Accession | NZ_CP083821 | ||
Organism | Enterobacter cloacae subsp. cloacae strain 12961-yvys |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | LCD47_RS02595 | Protein ID | WP_139936978.1 |
Coordinates | 543088..543372 (+) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | V3EXX3 |
Locus tag | LCD47_RS02590 | Protein ID | WP_008501400.1 |
Coordinates | 542856..543098 (+) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LCD47_RS02575 (LCD47_02580) | 538856..539596 | + | 741 | WP_139936976.1 | KDGP aldolase family protein | - |
LCD47_RS02580 (LCD47_02585) | 539712..540848 | + | 1137 | WP_139936977.1 | lactonase family protein | - |
LCD47_RS02585 (LCD47_02590) | 540868..542778 | + | 1911 | WP_023619664.1 | PRD domain-containing protein | - |
LCD47_RS02590 (LCD47_02595) | 542856..543098 | + | 243 | WP_008501400.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
LCD47_RS02595 (LCD47_02600) | 543088..543372 | + | 285 | WP_139936978.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
LCD47_RS02600 (LCD47_02605) | 543376..543840 | - | 465 | WP_040020449.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
LCD47_RS02605 (LCD47_02610) | 543976..546114 | - | 2139 | WP_058660602.1 | anaerobic ribonucleoside-triphosphate reductase | - |
LCD47_RS02610 (LCD47_02615) | 546488..548131 | - | 1644 | WP_139936979.1 | alpha,alpha-phosphotrehalase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11028.96 Da Isoelectric Point: 10.4610
>T217443 WP_139936978.1 NZ_CP083821:543088-543372 [Enterobacter cloacae subsp. cloacae]
MTYELEFDPRALKEWSKLGETVKKQFRKKLAGVLVNPRIESARLHNLPDCYKIKLRSQGYRLVYQVQDNVVTIVVIAIGK
REKLTVYHDANKRL
MTYELEFDPRALKEWSKLGETVKKQFRKKLAGVLVNPRIESARLHNLPDCYKIKLRSQGYRLVYQVQDNVVTIVVIAIGK
REKLTVYHDANKRL
Download Length: 285 bp
>T217443 NZ_CP114308:4448419-4448637 [Klebsiella oxytoca]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGCTTACGACGTTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCTGATAATGAACTGGCGGTATTTTACTCAGCAGCCGATCATCGTCTTGCTGAAC
TGACGATGAATAAACTGTATGACAAGATCCCGCCATCGGTCTGGAAATTCATCCGCTAA
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGCTTACGACGTTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCTGATAATGAACTGGCGGTATTTTACTCAGCAGCCGATCATCGTCTTGCTGAAC
TGACGATGAATAAACTGTATGACAAGATCCCGCCATCGGTCTGGAAATTCATCCGCTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8972.37 Da Isoelectric Point: 5.0651
>AT217443 WP_008501400.1 NZ_CP083821:542856-543098 [Enterobacter cloacae subsp. cloacae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL
Download Length: 243 bp
>AT217443 NZ_CP114308:4448018-4448392 [Klebsiella oxytoca]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTTAATGACCCAACCTCAGCTGTCAATCTTCAGCTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCACTTAATTATAAAATTAAGTATGCTGAGGATAATAAGCTGGTGACTCAGCTTGACGAATATCTG
GATGACACTTTCGTGTTGTTCAGCAACTACGGCATTAACACTGCAGATCTGCAGAAATGGCGTAAATCAGGCAACAGGTT
ATTCCGCTGCTTTGTGAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAA
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTTAATGACCCAACCTCAGCTGTCAATCTTCAGCTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCACTTAATTATAAAATTAAGTATGCTGAGGATAATAAGCTGGTGACTCAGCTTGACGAATATCTG
GATGACACTTTCGTGTTGTTCAGCAACTACGGCATTAACACTGCAGATCTGCAGAAATGGCGTAAATCAGGCAACAGGTT
ATTCCGCTGCTTTGTGAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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