Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 542856..543372 Replicon chromosome
Accession NZ_CP083821
Organism Enterobacter cloacae subsp. cloacae strain 12961-yvys

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LCD47_RS02595 Protein ID WP_139936978.1
Coordinates 543088..543372 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag LCD47_RS02590 Protein ID WP_008501400.1
Coordinates 542856..543098 (+) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD47_RS02575 (LCD47_02580) 538856..539596 + 741 WP_139936976.1 KDGP aldolase family protein -
LCD47_RS02580 (LCD47_02585) 539712..540848 + 1137 WP_139936977.1 lactonase family protein -
LCD47_RS02585 (LCD47_02590) 540868..542778 + 1911 WP_023619664.1 PRD domain-containing protein -
LCD47_RS02590 (LCD47_02595) 542856..543098 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LCD47_RS02595 (LCD47_02600) 543088..543372 + 285 WP_139936978.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCD47_RS02600 (LCD47_02605) 543376..543840 - 465 WP_040020449.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LCD47_RS02605 (LCD47_02610) 543976..546114 - 2139 WP_058660602.1 anaerobic ribonucleoside-triphosphate reductase -
LCD47_RS02610 (LCD47_02615) 546488..548131 - 1644 WP_139936979.1 alpha,alpha-phosphotrehalase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 95 a.a.        Molecular weight: 11028.96 Da        Isoelectric Point: 10.4610

>T217443 WP_139936978.1 NZ_CP083821:543088-543372 [Enterobacter cloacae subsp. cloacae]
MTYELEFDPRALKEWSKLGETVKKQFRKKLAGVLVNPRIESARLHNLPDCYKIKLRSQGYRLVYQVQDNVVTIVVIAIGK
REKLTVYHDANKRL

Download         Length: 285 bp

>T217443 NZ_CP114308:4448419-4448637 [Klebsiella oxytoca]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGCTTACGACGTTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCTGATAATGAACTGGCGGTATTTTACTCAGCAGCCGATCATCGTCTTGCTGAAC
TGACGATGAATAAACTGTATGACAAGATCCCGCCATCGGTCTGGAAATTCATCCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT217443 WP_008501400.1 NZ_CP083821:542856-543098 [Enterobacter cloacae subsp. cloacae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT217443 NZ_CP114308:4448018-4448392 [Klebsiella oxytoca]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTTAATGACCCAACCTCAGCTGTCAATCTTCAGCTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCACTTAATTATAAAATTAAGTATGCTGAGGATAATAAGCTGGTGACTCAGCTTGACGAATATCTG
GATGACACTTTCGTGTTGTTCAGCAACTACGGCATTAACACTGCAGATCTGCAGAAATGGCGTAAATCAGGCAACAGGTT
ATTCCGCTGCTTTGTGAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References