Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3841738..3842395 Replicon chromosome
Accession NZ_CP083819
Organism Enterobacter roggenkampii strain 13840-yvys

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag LCD41_RS18525 Protein ID WP_021242050.1
Coordinates 3841738..3842148 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag LCD41_RS18530 Protein ID WP_006178375.1
Coordinates 3842129..3842395 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD41_RS18505 (LCD41_18540) 3837731..3839464 - 1734 WP_045415651.1 single-stranded-DNA-specific exonuclease RecJ -
LCD41_RS18510 (LCD41_18545) 3839470..3840183 - 714 WP_047745993.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LCD41_RS18515 (LCD41_18550) 3840212..3841108 - 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
LCD41_RS18520 (LCD41_18555) 3841210..3841731 + 522 WP_008499710.1 flavodoxin FldB -
LCD41_RS18525 (LCD41_18560) 3841738..3842148 - 411 WP_021242050.1 protein YgfX Toxin
LCD41_RS18530 (LCD41_18565) 3842129..3842395 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
LCD41_RS18535 (LCD41_18570) 3842690..3843670 + 981 WP_047745992.1 tRNA-modifying protein YgfZ -
LCD41_RS18540 (LCD41_18575) 3843755..3844414 - 660 WP_047745991.1 hemolysin III family protein -
LCD41_RS18545 (LCD41_18580) 3844680..3845411 + 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
LCD41_RS18550 (LCD41_18585) 3845528..3846961 + 1434 WP_023294510.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T217439 WP_021242050.1 NZ_CP083819:c3842148-3841738 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T217439 NZ_CP114307:c109873-109568 [Klebsiella oxytoca]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT217439 WP_006178375.1 NZ_CP083819:c3842395-3842129 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT217439 NZ_CP114307:c110093-109875 [Klebsiella oxytoca]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References