Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1641650..1642447 Replicon chromosome
Accession NZ_CP083819
Organism Enterobacter roggenkampii strain 13840-yvys

Toxin (Protein)


Gene name KacT Uniprot ID A0A155TD66
Locus tag LCD41_RS07900 Protein ID WP_032651255.1
Coordinates 1641926..1642447 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag LCD41_RS07895 Protein ID WP_008499829.1
Coordinates 1641650..1641919 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD41_RS07865 (LCD41_07880) 1637273..1637716 - 444 WP_047745123.1 helix-turn-helix domain-containing protein -
LCD41_RS07870 (LCD41_07885) 1637869..1639110 + 1242 WP_023343731.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
LCD41_RS07875 (LCD41_07890) 1639146..1639373 - 228 WP_008499832.1 YccJ family protein -
LCD41_RS07880 (LCD41_07895) 1639394..1639990 - 597 WP_008499831.1 NAD(P)H:quinone oxidoreductase -
LCD41_RS07885 (LCD41_07900) 1640382..1640552 + 171 WP_047745124.1 general stress protein -
LCD41_RS07890 (LCD41_07905) 1640671..1641588 + 918 WP_023292825.1 DMT family transporter -
LCD41_RS07895 (LCD41_07910) 1641650..1641919 + 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
LCD41_RS07900 (LCD41_07915) 1641926..1642447 + 522 WP_032651255.1 GNAT family N-acetyltransferase Toxin
LCD41_RS07905 (LCD41_07920) 1642521..1643843 - 1323 WP_008499826.1 pyrimidine utilization transport protein G -
LCD41_RS07910 (LCD41_07925) 1643865..1644359 - 495 WP_023292823.1 pyrimidine utilization flavin reductase protein F -
LCD41_RS07915 (LCD41_07930) 1644369..1644959 - 591 WP_047745125.1 malonic semialdehyde reductase -
LCD41_RS07920 (LCD41_07935) 1644969..1645769 - 801 WP_021240807.1 pyrimidine utilization protein D -
LCD41_RS07925 (LCD41_07940) 1645777..1646163 - 387 WP_047745126.1 pyrimidine utilization protein C -
LCD41_RS07930 (LCD41_07945) 1646175..1646864 - 690 WP_047745127.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19714.46 Da        Isoelectric Point: 7.0497

>T217430 WP_032651255.1 NZ_CP083819:1641926-1642447 [Enterobacter roggenkampii]
VDNLTIEMFSEGKDYDFRDFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAIHKDLQGLEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNDQAKQFYLKQGFIPLTDENSHSLF
FPTKSIERLFEQA

Download         Length: 522 bp

>T217430 NZ_CP114305:84606-85181 [Klebsiella oxytoca]
ATGCGACATTCACCTTATCCGGTGATTTTAGATGCCTGTGTGTTATATCCGGCACGACTCAGAGATTTGCTGATGCACCT
GGGGATTGCCGGGCTGTATCAACCAAAATGGAGCCGCTGCATTCAGGATGAATGGTGCAGAAACTTGATTGCTAATCGGC
CTGACATTCTGCCAGAGACGCTTCAGCGTACTGTCAAAATGATGAATTCCGCCTTACCAGATGCCAATGTTACGGGATAT
AAGGGATTAATAAGTAATCTGCATCTGCCGGATCCCAACGACAGACATGTTCTTGCCGCAGCGATAAGAGCGAAAGCTGA
AATTATTGTAACGCTTAACCATAAGGACTTTCCGCCAGAACTTCTGGGTCCATATGAAATAGAAACGCTTCACCCTGATG
CGTTTATTTCCGATCTCTTCGATCTTAATCATGCTCTGACGCTTGAAGCCGTCAGGCGGCAGCGACTGTCTCTAAAACAT
CCATCTATGGCGGTCGATGAATTTCTTGAAATGCTGCTAAAGCAGGGTTTACCGATGACGGTAAAGGAATTAGCGCATTA
TCAGTATGCTATTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT217430 WP_008499829.1 NZ_CP083819:1641650-1641919 [Enterobacter roggenkampii]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp

>AT217430 NZ_CP114305:84151-84606 [Klebsiella oxytoca]
ATGACTACACTGACTCATCTCAACCTTCCCGATCGCCAGGAGAGCGAACTTGCGCAGCGCGGACAGCGTGAGCTTGCGGC
GTATCTTTCCACCAGGCTGGAAACACAGCGTATTGCCATTGTAGGAGAGGATGATAAAGCTCATACCATAGAGCTACCTA
CAAGTGCGCTGACATTGCTGATGGAGATATTGGGGGAGTTGGCTAGCGGAAATGCGGTACAAATCGTTCCCGTACATGCG
GAACTCACAACCCAGGAGGCGGCAAATATACTCAATGTCTCTCGTCCGCATATGGTTAAGCTCCTGGAAGCGAGGAAGCT
CCCATTTCATAAAACGGGGCGTCATCGCAGAGTGTTGTTTGCCGATCTTATGGAGTATAAGAAACGCAGGGAACAGGAGA
GCCTGGACGCGATGCAATCATTGGCCGATCAGGCGCAGGACTTAGGGATGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155TD66

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References