Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1029265..1029885 Replicon chromosome
Accession NZ_CP083819
Organism Enterobacter roggenkampii strain 13840-yvys

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag LCD41_RS04900 Protein ID WP_008499287.1
Coordinates 1029265..1029483 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag LCD41_RS04905 Protein ID WP_008499288.1
Coordinates 1029511..1029885 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD41_RS04870 (LCD41_04885) 1025278..1025538 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
LCD41_RS04875 (LCD41_04890) 1025541..1025681 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LCD41_RS04880 (LCD41_04895) 1025678..1026388 - 711 WP_045416683.1 GNAT family protein -
LCD41_RS04885 (LCD41_04900) 1026490..1027950 + 1461 WP_047745412.1 PLP-dependent aminotransferase family protein -
LCD41_RS04890 (LCD41_04905) 1027922..1028389 - 468 WP_008499285.1 YlaC family protein -
LCD41_RS04895 (LCD41_04910) 1028507..1029058 - 552 WP_047745410.1 maltose O-acetyltransferase -
LCD41_RS04900 (LCD41_04915) 1029265..1029483 - 219 WP_008499287.1 HHA domain-containing protein Toxin
LCD41_RS04905 (LCD41_04920) 1029511..1029885 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
LCD41_RS04910 (LCD41_04925) 1030395..1033541 - 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit AcrB -
LCD41_RS04915 (LCD41_04930) 1033564..1034757 - 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T217428 WP_008499287.1 NZ_CP083819:c1029483-1029265 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T217428 NZ_CP114285:5154350-5154643 [Flavobacterium flavigenum]
ATGGCTAAATACTATTTGACAAATAAAGCTGTTGAGGATTTATCTGAAATTTGGGATTATACAATTGAAGTTTGGTCTGA
AATGCAAGCTGAAAAGTATTACGGTTTGCTTTTATCAACATGTGACGATTTGGCAAATAATCCAGAACTTGGAAGGAATT
ATGATATAATTACAAAAGGAATATTGGGTTTTAAATCAGGCGAGCATATTATCTTTTACTCAATTATATCAAAGAATGAA
ATAGAAGTCGAAAGAATTCTTCACGGAATGATGGATTTGAAAAGCAAACTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT217428 WP_008499288.1 NZ_CP083819:c1029885-1029511 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT217428 NZ_CP114285:5154106-5154357 [Flavobacterium flavigenum]
ATGGGACGAAATACTTCTATATCGCTTGGTGATCATTTTGAAAGTTTTATTGAAAATAGTGTTAACGATGGAAGATTCAA
TAATGCAAGTGAAGTTGTCAGAGCGGGTCTGCGTCTTTTAGAAGATGAAGAAAACAGAATAATTGCTTTAAGAAAAGCAA
TAAATGACGGAATTGATAGTGGACGTGCAGTAGACTTTGATGCTAAAAAGTATCTTGAAGCTTTAAAAGCAAGAAAAAAA
TCAAATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References