Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 476999..477515 Replicon chromosome
Accession NZ_CP083819
Organism Enterobacter roggenkampii strain 13840-yvys

Toxin (Protein)


Gene name relE Uniprot ID A0A0W2HDR3
Locus tag LCD41_RS02290 Protein ID WP_008501399.1
Coordinates 477231..477515 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag LCD41_RS02285 Protein ID WP_008501400.1
Coordinates 476999..477241 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD41_RS02270 (LCD41_02275) 473089..473829 + 741 WP_021240686.1 KDGP aldolase family protein -
LCD41_RS02275 (LCD41_02280) 473855..474991 + 1137 WP_047744915.1 lactonase family protein -
LCD41_RS02280 (LCD41_02285) 475011..476921 + 1911 WP_047744914.1 PRD domain-containing protein -
LCD41_RS02285 (LCD41_02290) 476999..477241 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LCD41_RS02290 (LCD41_02295) 477231..477515 + 285 WP_008501399.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCD41_RS02295 (LCD41_02300) 477519..477983 - 465 WP_045408172.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LCD41_RS02300 (LCD41_02305) 478089..480227 - 2139 WP_008501397.1 anaerobic ribonucleoside-triphosphate reductase -
LCD41_RS02305 (LCD41_02310) 480597..481169 - 573 WP_047747541.1 fructose PTS transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10768.53 Da        Isoelectric Point: 10.3039

>T217426 WP_008501399.1 NZ_CP083819:477231-477515 [Enterobacter roggenkampii]
MTYELEFDPRALKEWSKLGDTVKNQFKKKLAGVLANPRVESARLHNLPDCYKIKLKASGYRLVYQVQDSVITVFVIAVGK
REKSAAYHDANKRL

Download         Length: 285 bp

>T217426 NZ_CP114281:c1244139-1243732 [Gallibacterium anatis]
ATGCTGAAATATATGTTGGATACCAATATCGTTATTTTTACGATAAAAAATAAGCCGCCACATTTGTTGCCGTTATTTAA
TGAAAATCAATCTATGCTTTGTATCAGCTCGATTACATTAATGGAGCTGGTTTATGGGGCAGAGAAAAGCAAAAAAACGG
CACAGAATCTTGCCGTTATTGAATCTTTCTGTGCAAGATTAGCCGTTTTGGATTATGACGAGGCAGCAGCATATCATAGT
GGGCAGATAAGAGCTGAATTAGCAAAAATTAGACAACCTATTGGATCATATGACGCAATGATCGCCGGGCACGCAAGGAG
TCTAGGCTTGACAGTTGTTACTAACAATATGAATGAGTTTTCACGGGTAGAGGGGTTAAGAGTAATTGATTGGAGTAAGC
CGATGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT217426 WP_008501400.1 NZ_CP083819:476999-477241 [Enterobacter roggenkampii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT217426 NZ_CP114281:c1244378-1244139 [Gallibacterium anatis]
ATGAGTGTAGTGACCGCAACTGTTTTTATGAATAATAAAAGCCAAGCTATCAGAATTCCGAAAGCTGCAGAATTACCTAA
TACTACAAAAAGTGTAAATATTATTATTCAAGGGGATATGCGTATTATCACACCTCTCAATAATGTTTGGGACAGCTGGT
TCAATGATTCAAATTCCGTATCGGACGATTTTATGTTAAGTCGTGAGCAACCACAGATGCAGGAAAGGGAAGAATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W2HDR3

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References