Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 120575..121182 Replicon chromosome
Accession NZ_CP083819
Organism Enterobacter roggenkampii strain 13840-yvys

Toxin (Protein)


Gene name hicA Uniprot ID A0A7H0N5B9
Locus tag LCD41_RS00580 Protein ID WP_071993467.1
Coordinates 120575..120760 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A155E9Y3
Locus tag LCD41_RS00585 Protein ID WP_032675741.1
Coordinates 120775..121182 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD41_RS00565 (LCD41_00570) 117007..118545 + 1539 WP_023617402.1 aldehyde dehydrogenase AldB -
LCD41_RS00570 (LCD41_00575) 118542..119507 - 966 WP_063435980.1 LysR family transcriptional regulator -
LCD41_RS00575 (LCD41_00580) 119625..120365 + 741 WP_021242443.1 MipA/OmpV family protein -
LCD41_RS00580 (LCD41_00585) 120575..120760 + 186 WP_071993467.1 type II toxin-antitoxin system HicA family toxin Toxin
LCD41_RS00585 (LCD41_00590) 120775..121182 + 408 WP_032675741.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LCD41_RS00590 (LCD41_00595) 121186..122262 - 1077 Protein_116 type I restriction enzyme HsdR N-terminal domain-containing protein -
LCD41_RS00595 (LCD41_00600) 122608..123303 - 696 WP_047745813.1 L-ribulose-5-phosphate 4-epimerase -
LCD41_RS00600 (LCD41_00605) 123297..124157 - 861 WP_047745811.1 L-ribulose-5-phosphate 3-epimerase -
LCD41_RS00605 (LCD41_00610) 124160..124813 - 654 WP_047745809.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6882.06 Da        Isoelectric Point: 11.2341

>T217425 WP_071993467.1 NZ_CP083819:120575-120760 [Enterobacter roggenkampii]
VKSADVITVLISHGWKCVRTKGSHHQFRHPEQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T217425 NZ_CP114281:1236781-1237080 [Gallibacterium anatis]
ATGACTTATAGCCTACAGTTTCACGAAAAAGCACTTAAAGAGTGGAAAAAACTAGATGAAACAACAAGAAGTCAATTAAA
AAAGAAACTTGCTGAACGCCTCCAAAATCCACATATTCAAGCTGATAGATTAAGTGGATTTTCTAATCCAACCTATAAGA
TTAAATTACGTTCTATCGGATATCGTCTTGTGTATGAGGTGAATGACGATATTATCACTGTTTTTGTGCTTTCTGTCGGC
AAGCGAAATAAATTGCAAGCCTACATCAATGCTCACCACAGGGCAGAAAAAATGTATTAG

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15010.78 Da        Isoelectric Point: 4.3897

>AT217425 WP_032675741.1 NZ_CP083819:120775-121182 [Enterobacter roggenkampii]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDNALPLPGNVEAHLESRPEDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPG

Download         Length: 408 bp

>AT217425 NZ_CP114281:1236531-1236791 [Gallibacterium anatis]
ATGAAAAATGTTCATAAAATACATACTGATGTTGTTGCCAGTATTACCTCGTTAAAACGAGACCCAATGAGAACGATTTA
TAACGATACCGGTAGTCAGGCTGTTGCTATTCTCAACCGTAATCAACCTGCATTTTATTGTATTACGCCTGAACTCTTTG
AGCATTTTCTCGAATTAGAAGAAAATGCTGAATTGGCAAAAATAGTGCAAGAACGCAAAAAAGAAGGGAAATTTATTAAG
GTGAATATTGATGACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0N5B9

Antitoxin

Source ID Structure
AlphaFold DB A0A155E9Y3

References