Detailed information of TA system TA217423

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3670830..3671487
• Replicon: chromosome
• Accession: NZ_CP083815
• Organism: Enterobacter asburiae strain 161373-yvys

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A1H8U0Q4
• Locus tag: LCD39_RS17910
• Protein ID: WP_021242050.1
• Coordinates: 3670830..3671240 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: LCD39_RS17915
• Protein ID: WP_246946637.1
• Coordinates: 3671221..3671487 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCD39_RS17890 (LCD39_17910)	3666823..3668556	-	1734	WP_246946636.1	single-stranded-DNA-specific exonuclease RecJ	-
LCD39_RS17895 (LCD39_17915)	3668562..3669275	-	714	WP_047060452.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LCD39_RS17900 (LCD39_17920)	3669304..3670200	-	897	WP_023309098.1	site-specific tyrosine recombinase XerD	-
LCD39_RS17905 (LCD39_17925)	3670302..3670823	+	522	WP_039262979.1	flavodoxin FldB	-
LCD39_RS17910 (LCD39_17930)	3670830..3671240	-	411	WP_021242050.1	protein YgfX	Toxin
LCD39_RS17915 (LCD39_17935)	3671221..3671487	-	267	WP_246946637.1	FAD assembly factor SdhE	Antitoxin
LCD39_RS17920 (LCD39_17940)	3671781..3672761	+	981	WP_033146590.1	tRNA-modifying protein YgfZ	-
LCD39_RS17925 (LCD39_17945)	3672836..3673495	-	660	WP_033146591.1	hemolysin III family protein	-
LCD39_RS17930 (LCD39_17950)	3673661..3673972	-	312	WP_033146592.1	N(4)-acetylcytidine aminohydrolase	-
LCD39_RS17935 (LCD39_17955)	3674024..3674755	+	732	WP_211438605.1	MurR/RpiR family transcriptional regulator	-
LCD39_RS17940 (LCD39_17960)	3674872..3676305	+	1434	WP_246946638.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16097.08 Da
• Isoelectric Point: 10.9468

>T217423 WP_021242050.1 NZ_CP083815:c3671240-3670830 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Nucleotide

• Length: 411 bp

>T217423 NZ_CP114281:832525-832707 [Gallibacterium anatis]
GTGGATAGTAAAACGTTAATAAAAATGATTGAAGAGGACGGTTGGATTTACCGCAACACAACAGGTAGCCACCGTCACTA
TACTCACCCAATCAAAAAAGGGATTGTTACCATTCCCCATCCAAAAAAGGATATAAAAAAGGGGACAGAACATTCCATAT
TAAAACAAGCAGGGCTGAAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10554.04 Da
• Isoelectric Point: 5.6963

>AT217423 WP_246946637.1 NZ_CP083815:c3671487-3671221 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFQYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT217423 NZ_CP114281:832737-833147 [Gallibacterium anatis]
ATGTTATATCCTATTGCTATTGAACCAGGTGATGAAACTCACGCTTATGGCGTCATCGTACCTGATATACCGGGCTGCTT
CTCTGCAGGTGATACCTTAGAAGAAGCTTATGCCAATGTGAAAGATGCCATTGTTGGTCATCTTGAATTGATGGTTGAAG
AAGGTTTAGAAATTCCAAAACCAACTTCAATCGAAAATCATCGCCATAATCCAGACTTTACCGATTATGGAATGTTTTTT
GGCGTTGTTGATGTGGATATTAGTCATCTACTGGGCAAAACCGAACGTATTAATATCACTATGCCATCGTATTTAATTAA
GCGGATTGATGATTTTGTTGCTACTCATCCGCAATATAAAAACCGAAGTCATTTTCTTGCCTCAGTTAGCGCAGATAAAA
TAATGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A1H8U0Q4