Detailed information of TA system TA217422

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 3453332..3454065
• Replicon: chromosome
• Accession: NZ_CP083815
• Organism: Enterobacter asburiae strain 161373-yvys

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: LCD39_RS16845
• Protein ID: WP_078309458.1
• Coordinates: 3453736..3454065 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: LCD39_RS16840
• Protein ID: WP_078309456.1
• Coordinates: 3453332..3453697 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCD39_RS16800 (LCD39_16820)	3448960..3449847	+	888	WP_078309444.1	50S ribosome-binding GTPase	-
LCD39_RS16805 (LCD39_16825)	3450060..3450218	+	159	WP_101706469.1	hypothetical protein	-
LCD39_RS16810 (LCD39_16830)	3450344..3450808	+	465	WP_078309448.1	hypothetical protein	-
LCD39_RS16815 (LCD39_16835)	3450843..3451184	+	342	WP_078309449.1	hypothetical protein	-
LCD39_RS16820 (LCD39_16840)	3451276..3452097	+	822	WP_078309451.1	DUF932 domain-containing protein	-
LCD39_RS16825 (LCD39_16845)	3452128..3452571	+	444	WP_078309452.1	antirestriction protein	-
LCD39_RS16830 (LCD39_16850)	3452584..3453126	+	543	WP_214574529.1	DNA repair protein RadC	-
LCD39_RS16835 (LCD39_16855)	3453123..3453306	+	184	Protein_3297	DUF987 family protein	-
LCD39_RS16840 (LCD39_16860)	3453332..3453697	+	366	WP_078309456.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
LCD39_RS16845 (LCD39_16865)	3453736..3454065	+	330	WP_078309458.1	TA system toxin CbtA family protein	Toxin
LCD39_RS16850 (LCD39_16870)	3454540..3454806	+	267	WP_246946564.1	DinI family protein	-
LCD39_RS16855 (LCD39_16875)	3454936..3456747	-	1812	WP_246946565.1	hypothetical protein	-
LCD39_RS16860 (LCD39_16880)	3456747..3457427	-	681	WP_246946566.1	DUF2612 domain-containing protein	-
LCD39_RS16865 (LCD39_16885)	3457424..3458623	-	1200	WP_246946567.1	baseplate J/gp47 family protein	-
LCD39_RS16870 (LCD39_16890)	3458624..3458977	-	354	WP_094935658.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	luxS	3432427..3508817	76390

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (2-107)

Antitoxin

• Antitoxin CbeA (17-117)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12303.17 Da
• Isoelectric Point: 8.5043

>T217422 WP_078309458.1 NZ_CP083815:3453736-3454065 [Enterobacter asburiae]
MQIISSAPTRAAPLSLSPVEIWQRLLTHLLSQHYGLTLNDTPFSYETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILMARRSTGLLKTTVK

Nucleotide

• Length: 330 bp

>T217422 NZ_CP114281:755104-755388 [Gallibacterium anatis]
ATGGCAGAACAATTAAAAGACTTTGATATGTCAGAACATTTACGCACAGAAGAAGAAATACAGCTCTATCTTAATGAGAT
TTTAAGTGAGGGCGATATTGATTTATTGCTTTCTGCATTAGGTGATATAGCGAAAGCGAGAAATATGAGTCAAATTGCTC
GAGAAGTGGGGGTAACAAGAGAAGGGTTATATAAAGCTCTTTCTGGGCGAGGCAATCCAACATTTGCCACTGTGTTTAAG
GTAATGCAGGCGTTAAATTTGAATTTAGAAGTAAAACACGCTTAA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13427.12 Da
• Isoelectric Point: 5.4451

>AT217422 WP_078309456.1 NZ_CP083815:3453332-3453697 [Enterobacter asburiae]
MNNHSESGTRPENSAIQQWGLKRAITPCFGARLVQEGNRLHYLADRAGFSGAFTDDVAMHLDQAFPLMMKQLELMLTSGE
LNPSHPHCVTLYHNGLTCEADTLGSCGYVYIAIYPEQTEPQ

Nucleotide

• Length: 366 bp

>AT217422 NZ_CP114281:754806-755102 [Gallibacterium anatis]
ATGATTCAGATAAAATCAACAGAAGCCTTTGATAAATGGCTAGATAATCTTAAGGATTTGCGGGCAAGGGCTAAAATTCA
AGTGCGGATTAAACGATTACAGCTTGGCAATTTTGGTGATGTAAAGCCGATAGGTGAAGGGTTATCTGAATTAAGAATAA
CAGAAGGGAAAGGCTATCGCCTGTACTTGAAAAATCAAAATGGGGTGATTGTGATTTTGTTATGCGGTGGCGACAAATCC
ACACAGAAAGCGGATATTGAGAAAGCAAAATCGTTAGCAAAGATATTAGGAGTTTAA