Detailed information of TA system TA217411

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1026763..1027383
• Replicon: chromosome
• Accession: NZ_CP083815
• Organism: Enterobacter asburiae strain 161373-yvys

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A1H8SI38
• Locus tag: LCD39_RS04910
• Protein ID: WP_008499287.1
• Coordinates: 1026763..1026981 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: LCD39_RS04915
• Protein ID: WP_246947148.1
• Coordinates: 1027009..1027383 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCD39_RS04880 (LCD39_04885)	1022777..1023037	+	261	WP_010428154.1	type B 50S ribosomal protein L31	-
LCD39_RS04885 (LCD39_04890)	1023040..1023180	+	141	WP_167818673.1	type B 50S ribosomal protein L36	-
LCD39_RS04890 (LCD39_04895)	1023177..1023887	-	711	WP_246947143.1	GNAT family protein	-
LCD39_RS04895 (LCD39_04900)	1023989..1025449	+	1461	WP_246947145.1	PLP-dependent aminotransferase family protein	-
LCD39_RS04900 (LCD39_04905)	1025421..1025888	-	468	WP_023310598.1	YlaC family protein	-
LCD39_RS04905 (LCD39_04910)	1026006..1026557	-	552	WP_246947146.1	maltose O-acetyltransferase	-
LCD39_RS04910 (LCD39_04915)	1026763..1026981	-	219	WP_008499287.1	HHA domain-containing protein	Toxin
LCD39_RS04915 (LCD39_04920)	1027009..1027383	-	375	WP_246947148.1	Hha toxicity modulator TomB	Antitoxin
LCD39_RS04920 (LCD39_04925)	1027895..1031041	-	3147	WP_029741964.1	multidrug efflux RND transporter permease subunit AcrB	-
LCD39_RS04925 (LCD39_04930)	1031064..1032257	-	1194	WP_029741963.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1021525..1022493	968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-114)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8612.00 Da
• Isoelectric Point: 8.9008

>T217411 WP_008499287.1 NZ_CP083815:c1026981-1026763 [Enterobacter asburiae]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Nucleotide

• Length: 219 bp

>T217411 NZ_CP114280:1723234-1723563 [Dickeya lacustris]
ATGAAAAATCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTGTCTGTCTGGCAAATGTTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACGCTAAACGACACGCCGTTTAGTGATAAAACAGTTATTCAGGAACATATTA
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAATACGGGCTTGTCCGTATCGACCGAAAGGGATTT
TCGTGGCAAGAACAAACCCCGTATATTTCCGTAGTGGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14495.31 Da
• Isoelectric Point: 4.8886

>AT217411 WP_246947148.1 NZ_CP083815:c1027383-1027009 [Enterobacter asburiae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKTGNRLFRCFVNVSRANPVSLSC

Nucleotide

• Length: 375 bp

>AT217411 NZ_CP114280:1722896-1723213 [Dickeya lacustris]
ATGAGCAACACCACATGGGGCCTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGATGCCGAATGTCTTAAGCTGGATGTGGCATTTCCGC
ATTTTATCAGCCAGATGGACTCGATGCTCACCTCTGGTGAAATGAACCCTCACCATGCCCATTGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCAACGCTAA

Structures

Toxin

• AlphaFold DB: A0A1H8SI38