Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 903599..904228 Replicon chromosome
Accession NC_008555
Organism Listeria welshimeri serovar 6b str. SLCC5334

Toxin (Protein)


Gene name pemK Uniprot ID A0A6Z2PJ29
Locus tag LWE_RS04420 Protein ID WP_031695189.1
Coordinates 903881..904228 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7U7S1X0
Locus tag LWE_RS04415 Protein ID WP_003766128.1
Coordinates 903599..903877 (+) Length 93 a.a.

Genomic Context


LWE_RS04395LWE_RS04400LWE_RS04405LWE_RS04410LWE_RS04415LWE_RS04420LWE_RS04425LWE_RS04430LWE_RS04435LWE_RS04440LWE_RS04445LWE_RS04450LWE_RS04455
Location: 898901..900382 (1482 bp)
Type: Others
Protein ID: WP_011701701.1
Location: 900531..901919 (1389 bp)
Type: Others
Protein ID: WP_011701702.1
Location: 901912..902268 (357 bp)
Type: Others
Protein ID: WP_011701703.1
Location: 902287..903393 (1107 bp)
Type: Others
Protein ID: WP_011701704.1
Location: 903599..903877 (279 bp)
Type: Antitoxin
Protein ID: WP_003766128.1
Location: 903881..904228 (348 bp)
Type: Toxin
Protein ID: WP_031695189.1
Location: 904476..905312 (837 bp)
Type: Others
Protein ID: WP_011701705.1
Location: 905318..905674 (357 bp)
Type: Others
Protein ID: WP_003721457.1
Location: 905677..906087 (411 bp)
Type: Others
Protein ID: WP_011701706.1
Location: 906104..907108 (1005 bp)
Type: Others
Protein ID: WP_011701707.1
Location: 907257..907601 (345 bp)
Type: Others
Protein ID: WP_011701708.1
Location: 907585..908058 (474 bp)
Type: Others
Protein ID: WP_011701709.1
Location: 908036..908815 (780 bp)
Type: Others
Protein ID: WP_011701710.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LWE_RS04395898901..900382+1482WP_011701701.1PH domain-containing protein-
LWE_RS04400900531..901919+1389WP_011701702.1protoporphyrinogen oxidase-
LWE_RS04405901912..902268+357WP_011701703.1holo-ACP synthase-
LWE_RS04410902287..903393+1107WP_011701704.1alanine racemase-
LWE_RS04415903599..903877+279WP_003766128.1CopG family ribbon-helix-helix proteinAntitoxin
LWE_RS04420903881..904228+348WP_031695189.1type II toxin-antitoxin system PemK/MazF family toxinToxin
LWE_RS04425904476..905312+837WP_011701705.1STAS domain-containing protein-
LWE_RS04430905318..905674+357WP_003721457.1STAS domain-containing protein-
LWE_RS04435905677..906087+411WP_011701706.1anti-sigma regulatory factor-
LWE_RS04440906104..907108+1005WP_011701707.1PP2C family protein-serine/threonine phosphatase-
LWE_RS04445907257..907601+345WP_011701708.1anti sigma b factor antagonist RsbV-
LWE_RS04450907585..908058+474WP_011701709.1anti-sigma B factor RsbW-
LWE_RS04455908036..908815+780WP_011701710.1RNA polymerase sigma factor SigB-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-109)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 116 a.a.        Molecular weight: 12801.89 Da        Isoelectric Point: 7.2038

>T21741 WP_031695189.1 NC_008555:903881-904228 [Listeria welshimeri serovar 6b str. SLCC5334]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMAKVNKALEVSLGVVEF

Download         Length: 348 bp

>T21741 NC_008555:903881-904228 [Listeria welshimeri serovar 6b str. SLCC5334]
CTGATGGTGAAGCGTGGTGACGTATACTACGCGGACCTTTCCCCCGTGGTCGGGAGCGAGCAAGGGGGAATAAGGCCTGT
TCTCATCATACAGAACGATATTGGTAATAGATTCAGTCCAACTGTGATTGTGGCAGCAATAACCGCAAAAATTCAAAAAG
CGAAGTTGCCAACACACGTGGAAGCTACTCGTAAAGATGGCTTTGAGAGAGATTCTGTCATTCTTTTAGAACAAATTAGA
ACGATTGACAAACAACGCCTGACAGATAAAATTACACATTTGGACGAGGAACTAATGGCCAAGGTAAATAAGGCGCTTGA
AGTCAGCCTAGGAGTAGTAGAATTTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10575.05 Da        Isoelectric Point: 4.2980

>AT21741 WP_003766128.1 NC_008555:903599-903877 [Listeria welshimeri serovar 6b str. SLCC5334]
VLEKEKRTIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVEA
EAEDRNISILGG

Download         Length: 279 bp

>AT21741 NC_008555:903599-903877 [Listeria welshimeri serovar 6b str. SLCC5334]
GTGTTAGAGAAAGAAAAACGGACAATAATATCCGTAGAACTGACACAGGAAATGGTACAGGAACTCGACGTAGTTGTAGA
AAAAGAAAAAATGGGGCGGAGTGAAGTTATAATGGAAGCAACGCAACAGTTTTTGCAAGAGAAAAGGGCTCGTGAACTTA
GAGACGAGATGGAACGCGGCTATGCAGAAATGGCAACAATTAATTTTGCTATTGCATGCGAGTGTACCCATGTCGAAGCA
GAAGCAGAAGATAGGAATATTAGTATTTTAGGAGGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A6Z2PJ29


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U7S1X0

References