Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pemK-mazE/MazF(toxin) |
Location | 903599..904228 | Replicon | chromosome |
Accession | NC_008555 | ||
Organism | Listeria welshimeri serovar 6b str. SLCC5334 |
Toxin (Protein)
Gene name | pemK | Uniprot ID | A0A6Z2PJ29 |
Locus tag | LWE_RS04420 | Protein ID | WP_031695189.1 |
Coordinates | 903881..904228 (+) | Length | 116 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | A0A7U7S1X0 |
Locus tag | LWE_RS04415 | Protein ID | WP_003766128.1 |
Coordinates | 903599..903877 (+) | Length | 93 a.a. |
Genomic Context
Location: 898901..900382 (1482 bp)
Type: Others
Protein ID: WP_011701701.1
Type: Others
Protein ID: WP_011701701.1
Location: 900531..901919 (1389 bp)
Type: Others
Protein ID: WP_011701702.1
Type: Others
Protein ID: WP_011701702.1
Location: 901912..902268 (357 bp)
Type: Others
Protein ID: WP_011701703.1
Type: Others
Protein ID: WP_011701703.1
Location: 902287..903393 (1107 bp)
Type: Others
Protein ID: WP_011701704.1
Type: Others
Protein ID: WP_011701704.1
Location: 903599..903877 (279 bp)
Type: Antitoxin
Protein ID: WP_003766128.1
Type: Antitoxin
Protein ID: WP_003766128.1
Location: 903881..904228 (348 bp)
Type: Toxin
Protein ID: WP_031695189.1
Type: Toxin
Protein ID: WP_031695189.1
Location: 904476..905312 (837 bp)
Type: Others
Protein ID: WP_011701705.1
Type: Others
Protein ID: WP_011701705.1
Location: 905318..905674 (357 bp)
Type: Others
Protein ID: WP_003721457.1
Type: Others
Protein ID: WP_003721457.1
Location: 905677..906087 (411 bp)
Type: Others
Protein ID: WP_011701706.1
Type: Others
Protein ID: WP_011701706.1
Location: 906104..907108 (1005 bp)
Type: Others
Protein ID: WP_011701707.1
Type: Others
Protein ID: WP_011701707.1
Location: 907257..907601 (345 bp)
Type: Others
Protein ID: WP_011701708.1
Type: Others
Protein ID: WP_011701708.1
Location: 907585..908058 (474 bp)
Type: Others
Protein ID: WP_011701709.1
Type: Others
Protein ID: WP_011701709.1
Location: 908036..908815 (780 bp)
Type: Others
Protein ID: WP_011701710.1
Type: Others
Protein ID: WP_011701710.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LWE_RS04395 | 898901..900382 | + | 1482 | WP_011701701.1 | PH domain-containing protein | - |
LWE_RS04400 | 900531..901919 | + | 1389 | WP_011701702.1 | protoporphyrinogen oxidase | - |
LWE_RS04405 | 901912..902268 | + | 357 | WP_011701703.1 | holo-ACP synthase | - |
LWE_RS04410 | 902287..903393 | + | 1107 | WP_011701704.1 | alanine racemase | - |
LWE_RS04415 | 903599..903877 | + | 279 | WP_003766128.1 | CopG family ribbon-helix-helix protein | Antitoxin |
LWE_RS04420 | 903881..904228 | + | 348 | WP_031695189.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
LWE_RS04425 | 904476..905312 | + | 837 | WP_011701705.1 | STAS domain-containing protein | - |
LWE_RS04430 | 905318..905674 | + | 357 | WP_003721457.1 | STAS domain-containing protein | - |
LWE_RS04435 | 905677..906087 | + | 411 | WP_011701706.1 | anti-sigma regulatory factor | - |
LWE_RS04440 | 906104..907108 | + | 1005 | WP_011701707.1 | PP2C family protein-serine/threonine phosphatase | - |
LWE_RS04445 | 907257..907601 | + | 345 | WP_011701708.1 | anti sigma b factor antagonist RsbV | - |
LWE_RS04450 | 907585..908058 | + | 474 | WP_011701709.1 | anti-sigma B factor RsbW | - |
LWE_RS04455 | 908036..908815 | + | 780 | WP_011701710.1 | RNA polymerase sigma factor SigB | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 12801.89 Da Isoelectric Point: 7.2038
>T21741 WP_031695189.1 NC_008555:903881-904228 [Listeria welshimeri serovar 6b str. SLCC5334]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMAKVNKALEVSLGVVEF
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMAKVNKALEVSLGVVEF
Download Length: 348 bp
>T21741 NC_008555:903881-904228 [Listeria welshimeri serovar 6b str. SLCC5334]
CTGATGGTGAAGCGTGGTGACGTATACTACGCGGACCTTTCCCCCGTGGTCGGGAGCGAGCAAGGGGGAATAAGGCCTGT
TCTCATCATACAGAACGATATTGGTAATAGATTCAGTCCAACTGTGATTGTGGCAGCAATAACCGCAAAAATTCAAAAAG
CGAAGTTGCCAACACACGTGGAAGCTACTCGTAAAGATGGCTTTGAGAGAGATTCTGTCATTCTTTTAGAACAAATTAGA
ACGATTGACAAACAACGCCTGACAGATAAAATTACACATTTGGACGAGGAACTAATGGCCAAGGTAAATAAGGCGCTTGA
AGTCAGCCTAGGAGTAGTAGAATTTTAA
CTGATGGTGAAGCGTGGTGACGTATACTACGCGGACCTTTCCCCCGTGGTCGGGAGCGAGCAAGGGGGAATAAGGCCTGT
TCTCATCATACAGAACGATATTGGTAATAGATTCAGTCCAACTGTGATTGTGGCAGCAATAACCGCAAAAATTCAAAAAG
CGAAGTTGCCAACACACGTGGAAGCTACTCGTAAAGATGGCTTTGAGAGAGATTCTGTCATTCTTTTAGAACAAATTAGA
ACGATTGACAAACAACGCCTGACAGATAAAATTACACATTTGGACGAGGAACTAATGGCCAAGGTAAATAAGGCGCTTGA
AGTCAGCCTAGGAGTAGTAGAATTTTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10575.05 Da Isoelectric Point: 4.2980
>AT21741 WP_003766128.1 NC_008555:903599-903877 [Listeria welshimeri serovar 6b str. SLCC5334]
VLEKEKRTIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVEA
EAEDRNISILGG
VLEKEKRTIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVEA
EAEDRNISILGG
Download Length: 279 bp
>AT21741 NC_008555:903599-903877 [Listeria welshimeri serovar 6b str. SLCC5334]
GTGTTAGAGAAAGAAAAACGGACAATAATATCCGTAGAACTGACACAGGAAATGGTACAGGAACTCGACGTAGTTGTAGA
AAAAGAAAAAATGGGGCGGAGTGAAGTTATAATGGAAGCAACGCAACAGTTTTTGCAAGAGAAAAGGGCTCGTGAACTTA
GAGACGAGATGGAACGCGGCTATGCAGAAATGGCAACAATTAATTTTGCTATTGCATGCGAGTGTACCCATGTCGAAGCA
GAAGCAGAAGATAGGAATATTAGTATTTTAGGAGGTTAA
GTGTTAGAGAAAGAAAAACGGACAATAATATCCGTAGAACTGACACAGGAAATGGTACAGGAACTCGACGTAGTTGTAGA
AAAAGAAAAAATGGGGCGGAGTGAAGTTATAATGGAAGCAACGCAACAGTTTTTGCAAGAGAAAAGGGCTCGTGAACTTA
GAGACGAGATGGAACGCGGCTATGCAGAAATGGCAACAATTAATTTTGCTATTGCATGCGAGTGTACCCATGTCGAAGCA
GAAGCAGAAGATAGGAATATTAGTATTTTAGGAGGTTAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6Z2PJ29 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U7S1X0 |