Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 903599..904228 Replicon chromosome
Accession NC_008555
Organism Listeria welshimeri serovar 6b str. SLCC5334

Toxin (Protein)


Gene name pemK Uniprot ID A0A6Z2PJ29
Locus tag LWE_RS04420 Protein ID WP_031695189.1
Coordinates 903881..904228 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7U7S1X0
Locus tag LWE_RS04415 Protein ID WP_003766128.1
Coordinates 903599..903877 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LWE_RS04395 898901..900382 + 1482 WP_011701701.1 PH domain-containing protein -
LWE_RS04400 900531..901919 + 1389 WP_011701702.1 protoporphyrinogen oxidase -
LWE_RS04405 901912..902268 + 357 WP_011701703.1 holo-ACP synthase -
LWE_RS04410 902287..903393 + 1107 WP_011701704.1 alanine racemase -
LWE_RS04415 903599..903877 + 279 WP_003766128.1 CopG family ribbon-helix-helix protein Antitoxin
LWE_RS04420 903881..904228 + 348 WP_031695189.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LWE_RS04425 904476..905312 + 837 WP_011701705.1 STAS domain-containing protein -
LWE_RS04430 905318..905674 + 357 WP_003721457.1 STAS domain-containing protein -
LWE_RS04435 905677..906087 + 411 WP_011701706.1 anti-sigma regulatory factor -
LWE_RS04440 906104..907108 + 1005 WP_011701707.1 PP2C family protein-serine/threonine phosphatase -
LWE_RS04445 907257..907601 + 345 WP_011701708.1 anti sigma b factor antagonist RsbV -
LWE_RS04450 907585..908058 + 474 WP_011701709.1 anti-sigma B factor RsbW -
LWE_RS04455 908036..908815 + 780 WP_011701710.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12801.89 Da        Isoelectric Point: 7.2038

>T21741 WP_031695189.1 NC_008555:903881-904228 [Listeria welshimeri serovar 6b str. SLCC5334]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMAKVNKALEVSLGVVEF

Download         Length: 348 bp

>T21741 NC_008555:903881-904228 [Listeria welshimeri serovar 6b str. SLCC5334]
CTGATGGTGAAGCGTGGTGACGTATACTACGCGGACCTTTCCCCCGTGGTCGGGAGCGAGCAAGGGGGAATAAGGCCTGT
TCTCATCATACAGAACGATATTGGTAATAGATTCAGTCCAACTGTGATTGTGGCAGCAATAACCGCAAAAATTCAAAAAG
CGAAGTTGCCAACACACGTGGAAGCTACTCGTAAAGATGGCTTTGAGAGAGATTCTGTCATTCTTTTAGAACAAATTAGA
ACGATTGACAAACAACGCCTGACAGATAAAATTACACATTTGGACGAGGAACTAATGGCCAAGGTAAATAAGGCGCTTGA
AGTCAGCCTAGGAGTAGTAGAATTTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10575.05 Da        Isoelectric Point: 4.2980

>AT21741 WP_003766128.1 NC_008555:903599-903877 [Listeria welshimeri serovar 6b str. SLCC5334]
VLEKEKRTIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVEA
EAEDRNISILGG

Download         Length: 279 bp

>AT21741 NC_008555:903599-903877 [Listeria welshimeri serovar 6b str. SLCC5334]
GTGTTAGAGAAAGAAAAACGGACAATAATATCCGTAGAACTGACACAGGAAATGGTACAGGAACTCGACGTAGTTGTAGA
AAAAGAAAAAATGGGGCGGAGTGAAGTTATAATGGAAGCAACGCAACAGTTTTTGCAAGAGAAAAGGGCTCGTGAACTTA
GAGACGAGATGGAACGCGGCTATGCAGAAATGGCAACAATTAATTTTGCTATTGCATGCGAGTGTACCCATGTCGAAGCA
GAAGCAGAAGATAGGAATATTAGTATTTTAGGAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6Z2PJ29

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7S1X0

References