Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 522115..522929 Replicon chromosome
Accession NZ_CP083815
Organism Enterobacter asburiae strain 161373-yvys

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag LCD39_RS02465 Protein ID WP_023312605.1
Coordinates 522115..522492 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag LCD39_RS02470 Protein ID WP_023312604.1
Coordinates 522555..522929 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD39_RS02440 (LCD39_02440) 517948..519207 - 1260 WP_063850386.1 integrase arm-type DNA-binding domain-containing protein -
LCD39_RS02445 (LCD39_02445) 519537..520334 - 798 WP_023312609.1 helix-turn-helix transcriptional regulator -
LCD39_RS02450 (LCD39_02450) 520478..521323 - 846 WP_023312608.1 DUF4942 domain-containing protein -
LCD39_RS02455 (LCD39_02455) 521394..521597 - 204 WP_023312607.1 DUF957 domain-containing protein -
LCD39_RS02460 (LCD39_02460) 521627..522118 - 492 WP_023312606.1 DUF5983 family protein -
LCD39_RS02465 (LCD39_02465) 522115..522492 - 378 WP_023312605.1 TA system toxin CbtA family protein Toxin
LCD39_RS02470 (LCD39_02470) 522555..522929 - 375 WP_023312604.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LCD39_RS02475 (LCD39_02475) 522961..523182 - 222 WP_023312603.1 DUF987 domain-containing protein -
LCD39_RS02480 (LCD39_02480) 523194..523673 - 480 WP_023312602.1 DNA repair protein RadC -
LCD39_RS02485 (LCD39_02485) 523684..524163 - 480 WP_075204438.1 antirestriction protein -
LCD39_RS02490 (LCD39_02490) 524288..524497 - 210 WP_160311370.1 hypothetical protein -
LCD39_RS02495 (LCD39_02495) 524516..525334 - 819 WP_023312600.1 DUF932 domain-containing protein -
LCD39_RS02500 (LCD39_02500) 525450..525701 - 252 WP_023312599.1 DUF905 family protein -
LCD39_RS02505 (LCD39_02505) 525698..526369 - 672 WP_023312598.1 EcsC family protein -
LCD39_RS02510 (LCD39_02510) 526535..527716 - 1182 WP_154908439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 516922..561332 44410
- flank IS/Tn - - 516922..517890 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(2-112)

Antitoxin

Antitoxin CbeA

(20-118)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13995.88 Da        Isoelectric Point: 6.4781

>T217409 WP_023312605.1 NZ_CP083815:c522492-522115 [Enterobacter asburiae]
MQTQSIHPVRATASRPSPVDIWQTLLTYLLEQHYGLTLNDTPFGNDMVIQEHIEAGISLCDGVNFIVEKYELVRIDRHGF
STETQSPLIGSIDILRARKATGLMTRNDYKVVTDITTGKYSGGTR

Download         Length: 378 bp

>T217409 NZ_CP114278:3022498-3022932 [Brevundimonas vesicularis]
TTGATCGCGCTTTTGGACGTCAGCGTCCTGATCGCATTGATCGATCCAGCCCATACCGAGCATCTCACCGCCCACGCCTG
GTTCGCAAATGAGCATCAGGCTGGTTGGGCGACCTGCCCGCTGACCGAAAACGGCGCGCTTCGAATCCTCAGCAATCCGA
AATATCCGAACTCGCCGGGCGCGCCTGCGCAGGTGTTGCCCGCGCTTCATTCCTTGCTGAGCCAACCCGGCCATGCGTTC
TGGCCCGACGACATCAGTCTGCTGGGCGACCGTTTGATCGCGCAGGATCGCCTGCTCACCTCGGGCCAGTTGACGGATAC
CTATCTGCTGGCCTTAGCCGTCTCGAACGGCGGGCGGCTGGCCACGTTCGACCGACGCCTGGCGCCCGACGCGGTGAAGG
GCGGCAAGGCTGCCCTGCATCTCATAACGGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13708.50 Da        Isoelectric Point: 4.7593

>AT217409 WP_023312604.1 NZ_CP083815:c522929-522555 [Enterobacter asburiae]
MSDTESTDVGAIPQHTIASPWWGLKCDTTPCFGTRLVQEGNQLHFLSDRSNFTGTFHESEALQLNQAFPLMLKQLELMLV
SGELNPRHQHCVTLYHNGLICEADTLGSCGYIYLAIYPGEPPAA

Download         Length: 375 bp

>AT217409 NZ_CP114278:3022268-3022501 [Brevundimonas vesicularis]
ATGCGCACTACACTCGCCATCGACGACGACGTGCTGAACGCCGCACGGGCCATCGCGGTTCAGACCCGAACCTCTGTGGG
CGAAGTCATTTCCGATCTCGCGCGCCGCTCGATCACACAGGCCAAGCCGGACACGTCGCCCGAGTTCCGCAACGGCATTC
GTCTCCTGCCGCACCGCAAGGGCGCTGTGGTGACGACCGAACAGATTAACGCTCTGCGCGATGAGCTGCCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References