Detailed information of TA system TA021740

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 2512538..2514069
• Replicon: chromosome
• Accession: NC_008554
• Organism: Syntrophobacter fumaroxidans MPOB

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: A0LJY5
• Locus tag: SFUM_RS10630
• Protein ID: WP_011698906.1
• Coordinates: 2512538..2513470 (-)
• Length: 311 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: A0LJY6
• Locus tag: SFUM_RS10635
• Protein ID: WP_011698907.1
• Coordinates: 2513467..2514069 (-)
• Length: 201 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SFUM_RS10615	2507939..2508982	+	1044	WP_011698903.1	amino acid ABC transporter substrate-binding protein	-
SFUM_RS10620	2509090..2510433	+	1344	WP_011698904.1	citrate transporter	-
SFUM_RS10625	2510661..2512394	-	1734	WP_011698905.1	hypothetical protein	-
SFUM_RS10630	2512538..2513470	-	933	WP_011698906.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
SFUM_RS10635	2513467..2514069	-	603	WP_011698907.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
SFUM_RS10640	2514685..2514876	+	192	WP_150109487.1	hypothetical protein	-
SFUM_RS10645	2515162..2516295	+	1134	WP_011698909.1	Fic family protein	-
SFUM_RS22520	2517129..2517740	-	612	WP_011698910.1	preprotein translocase subunit SecG	-
SFUM_RS10660	2517759..2518523	-	765	WP_011698911.1	triose-phosphate isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (39-266)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (8-54)

Sequences

Toxin

Protein

• Length: 311 a.a.
• Molecular weight: 35432.12 Da
• Isoelectric Point: 9.6520

>T21740 WP_011698906.1 NC_008554:c2513470-2512538 [Syntrophobacter fumaroxidans MPOB]
VTQNRLRNVGASVRQRLLNLSKKKSEPFDLVLTRYALERLLYRIGRSEWRSRFLLKGAMLYTLWFDASYRPTRDMVLLGF
GPGQIAHLEGTFRALCEVAVEDDGLTFLKENVRGSEIRGESEYRGVRMQVTAILSGAVIPLQIDVAFGDVVLPGPEEVRY
PTILDLPAPEVLAYPRYTVVSEKFQAMVMLGIANSRMKDFYDIRELARRFEFDGLLLSRAIRATFEQRRTVLPAEIPLAL
TESFSHDRVKMTQWGAFIRKNRLMEEKVSLQEVAVFLTGFLMPPVRAAQQGEAFEMIWTAPGPWEPRNPT

Nucleotide

• Length: 933 bp

>T21740 NC_008554:c2513470-2512538 [Syntrophobacter fumaroxidans MPOB]
GTGACCCAAAACCGGCTTCGAAATGTTGGGGCGTCCGTCCGTCAGCGTCTCCTCAACCTTTCAAAGAAAAAGTCCGAACC
CTTTGATCTCGTGCTGACACGCTACGCCCTGGAAAGACTATTGTACAGAATAGGGCGCTCTGAATGGCGAAGCAGATTTC
TGCTCAAGGGTGCCATGCTGTACACCCTCTGGTTCGATGCGTCCTACCGCCCGACCAGGGACATGGTTCTTCTTGGCTTC
GGTCCAGGCCAAATCGCTCACCTGGAAGGGACTTTTCGTGCCTTGTGCGAAGTCGCCGTCGAGGACGACGGGCTAACTTT
TCTGAAGGAGAACGTTCGCGGTTCAGAGATCCGAGGTGAGAGCGAGTACCGGGGAGTACGGATGCAAGTGACCGCGATCC
TTTCAGGTGCCGTCATCCCCCTCCAAATTGACGTAGCTTTTGGTGACGTGGTTCTTCCTGGTCCGGAGGAAGTTCGCTAT
CCAACGATTCTGGACCTTCCGGCGCCTGAAGTCCTCGCCTACCCAAGGTACACCGTTGTCTCCGAGAAATTTCAGGCCAT
GGTGATGCTCGGCATTGCCAATAGTCGCATGAAGGATTTCTATGATATTCGGGAACTGGCACGGCGGTTCGAATTCGATG
GCTTGCTGCTCAGCCGGGCGATACGGGCTACGTTCGAACAGCGCAGGACCGTTCTGCCGGCGGAGATCCCGCTGGCTTTG
ACGGAATCTTTCTCCCATGACAGGGTCAAGATGACCCAATGGGGCGCATTCATCCGTAAGAATCGTCTCATGGAGGAGAA
GGTATCCTTGCAGGAGGTGGCGGTTTTTCTGACGGGTTTTCTAATGCCTCCCGTTCGTGCCGCCCAACAGGGAGAAGCAT
TCGAGATGATTTGGACCGCTCCGGGCCCTTGGGAACCGCGCAATCCGACCTGA

Antitoxin

Protein

• Length: 201 a.a.
• Molecular weight: 22763.56 Da
• Isoelectric Point: 9.8802

>AT21740 WP_011698907.1 NC_008554:c2514069-2513467 [Syntrophobacter fumaroxidans MPOB]
MAPTTTEQVLDLVEKAGVFRPRELDSYGIPREYLVRLCRKGLVRRVARGLYTFVDSDVSEHLSLAEASKKIPHGVICLLS
ALRFYGLTTQAPFEVWVAVDVKARKPRSDGLPLRIVRFSGAALRSGVEDQLIQGVKVRVYSPAKTVADCFKYRNKTGLDV
ALEALRECWRERRCTMDDLWRYAKICRVSNVMRPYLESLP

Nucleotide

• Length: 603 bp

>AT21740 NC_008554:c2514069-2513467 [Syntrophobacter fumaroxidans MPOB]
ATGGCACCGACAACGACGGAACAAGTTCTTGACCTTGTGGAGAAAGCAGGGGTCTTCCGTCCAAGGGAGCTCGATTCTTA
CGGTATTCCACGCGAATACCTCGTACGACTCTGTCGCAAGGGACTGGTGCGGCGCGTTGCGCGCGGGCTTTATACTTTCG
TGGATTCCGATGTGAGCGAGCACCTTAGCCTGGCAGAAGCATCCAAGAAAATCCCTCATGGTGTCATCTGCCTACTGTCC
GCACTTCGGTTCTACGGGCTGACGACGCAAGCCCCTTTTGAAGTCTGGGTCGCTGTCGACGTCAAGGCAAGGAAGCCCAG
GAGCGATGGTCTGCCACTCCGCATCGTGCGCTTCTCTGGCGCTGCACTCCGTTCCGGCGTTGAGGACCAGCTCATTCAGG
GTGTCAAAGTAAGGGTTTACAGCCCCGCGAAAACCGTTGCGGACTGTTTTAAGTACCGTAATAAGACCGGCCTTGACGTG
GCTCTGGAAGCCCTGCGCGAGTGCTGGCGCGAGCGCCGCTGTACCATGGACGACCTTTGGCGCTACGCTAAGATATGCCG
TGTTTCCAATGTGATGAGACCCTACCTGGAGTCACTGCCGTGA

Structures

Toxin

• AlphaFold DB: A0LJY5

Antitoxin

• AlphaFold DB: A0LJY6