21740

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 2512538..2514069 Replicon chromosome
Accession NC_008554
Organism Syntrophobacter fumaroxidans MPOB

Toxin (Protein)


Gene name rlegT Uniprot ID A0LJY5
Locus tag SFUM_RS10630 Protein ID WP_011698906.1
Coordinates 2512538..2513470 (-) Length 311 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID A0LJY6
Locus tag SFUM_RS10635 Protein ID WP_011698907.1
Coordinates 2513467..2514069 (-) Length 201 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFUM_RS10615 2507939..2508982 + 1044 WP_011698903.1 amino acid ABC transporter substrate-binding protein -
SFUM_RS10620 2509090..2510433 + 1344 WP_011698904.1 citrate transporter -
SFUM_RS10625 2510661..2512394 - 1734 WP_011698905.1 hypothetical protein -
SFUM_RS10630 2512538..2513470 - 933 WP_011698906.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
SFUM_RS10635 2513467..2514069 - 603 WP_011698907.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
SFUM_RS10640 2514685..2514876 + 192 WP_150109487.1 hypothetical protein -
SFUM_RS10645 2515162..2516295 + 1134 WP_011698909.1 Fic family protein -
SFUM_RS22520 2517129..2517740 - 612 WP_011698910.1 preprotein translocase subunit SecG -
SFUM_RS10660 2517759..2518523 - 765 WP_011698911.1 triose-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(39-266)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(8-54)


Sequences

Toxin        


Download         Length: 311 a.a.        Molecular weight: 35432.12 Da        Isoelectric Point: 9.6520

>T21740 WP_011698906.1 NC_008554:c2513470-2512538 [Syntrophobacter fumaroxidans MPOB]
VTQNRLRNVGASVRQRLLNLSKKKSEPFDLVLTRYALERLLYRIGRSEWRSRFLLKGAMLYTLWFDASYRPTRDMVLLGF
GPGQIAHLEGTFRALCEVAVEDDGLTFLKENVRGSEIRGESEYRGVRMQVTAILSGAVIPLQIDVAFGDVVLPGPEEVRY
PTILDLPAPEVLAYPRYTVVSEKFQAMVMLGIANSRMKDFYDIRELARRFEFDGLLLSRAIRATFEQRRTVLPAEIPLAL
TESFSHDRVKMTQWGAFIRKNRLMEEKVSLQEVAVFLTGFLMPPVRAAQQGEAFEMIWTAPGPWEPRNPT

Download         Length: 933 bp

>T21740 NC_008554:c2513470-2512538 [Syntrophobacter fumaroxidans MPOB]
GTGACCCAAAACCGGCTTCGAAATGTTGGGGCGTCCGTCCGTCAGCGTCTCCTCAACCTTTCAAAGAAAAAGTCCGAACC
CTTTGATCTCGTGCTGACACGCTACGCCCTGGAAAGACTATTGTACAGAATAGGGCGCTCTGAATGGCGAAGCAGATTTC
TGCTCAAGGGTGCCATGCTGTACACCCTCTGGTTCGATGCGTCCTACCGCCCGACCAGGGACATGGTTCTTCTTGGCTTC
GGTCCAGGCCAAATCGCTCACCTGGAAGGGACTTTTCGTGCCTTGTGCGAAGTCGCCGTCGAGGACGACGGGCTAACTTT
TCTGAAGGAGAACGTTCGCGGTTCAGAGATCCGAGGTGAGAGCGAGTACCGGGGAGTACGGATGCAAGTGACCGCGATCC
TTTCAGGTGCCGTCATCCCCCTCCAAATTGACGTAGCTTTTGGTGACGTGGTTCTTCCTGGTCCGGAGGAAGTTCGCTAT
CCAACGATTCTGGACCTTCCGGCGCCTGAAGTCCTCGCCTACCCAAGGTACACCGTTGTCTCCGAGAAATTTCAGGCCAT
GGTGATGCTCGGCATTGCCAATAGTCGCATGAAGGATTTCTATGATATTCGGGAACTGGCACGGCGGTTCGAATTCGATG
GCTTGCTGCTCAGCCGGGCGATACGGGCTACGTTCGAACAGCGCAGGACCGTTCTGCCGGCGGAGATCCCGCTGGCTTTG
ACGGAATCTTTCTCCCATGACAGGGTCAAGATGACCCAATGGGGCGCATTCATCCGTAAGAATCGTCTCATGGAGGAGAA
GGTATCCTTGCAGGAGGTGGCGGTTTTTCTGACGGGTTTTCTAATGCCTCCCGTTCGTGCCGCCCAACAGGGAGAAGCAT
TCGAGATGATTTGGACCGCTCCGGGCCCTTGGGAACCGCGCAATCCGACCTGA

Antitoxin


Download         Length: 201 a.a.        Molecular weight: 22763.56 Da        Isoelectric Point: 9.8802

>AT21740 WP_011698907.1 NC_008554:c2514069-2513467 [Syntrophobacter fumaroxidans MPOB]
MAPTTTEQVLDLVEKAGVFRPRELDSYGIPREYLVRLCRKGLVRRVARGLYTFVDSDVSEHLSLAEASKKIPHGVICLLS
ALRFYGLTTQAPFEVWVAVDVKARKPRSDGLPLRIVRFSGAALRSGVEDQLIQGVKVRVYSPAKTVADCFKYRNKTGLDV
ALEALRECWRERRCTMDDLWRYAKICRVSNVMRPYLESLP

Download         Length: 603 bp

>AT21740 NC_008554:c2514069-2513467 [Syntrophobacter fumaroxidans MPOB]
ATGGCACCGACAACGACGGAACAAGTTCTTGACCTTGTGGAGAAAGCAGGGGTCTTCCGTCCAAGGGAGCTCGATTCTTA
CGGTATTCCACGCGAATACCTCGTACGACTCTGTCGCAAGGGACTGGTGCGGCGCGTTGCGCGCGGGCTTTATACTTTCG
TGGATTCCGATGTGAGCGAGCACCTTAGCCTGGCAGAAGCATCCAAGAAAATCCCTCATGGTGTCATCTGCCTACTGTCC
GCACTTCGGTTCTACGGGCTGACGACGCAAGCCCCTTTTGAAGTCTGGGTCGCTGTCGACGTCAAGGCAAGGAAGCCCAG
GAGCGATGGTCTGCCACTCCGCATCGTGCGCTTCTCTGGCGCTGCACTCCGTTCCGGCGTTGAGGACCAGCTCATTCAGG
GTGTCAAAGTAAGGGTTTACAGCCCCGCGAAAACCGTTGCGGACTGTTTTAAGTACCGTAATAAGACCGGCCTTGACGTG
GCTCTGGAAGCCCTGCGCGAGTGCTGGCGCGAGCGCCGCTGTACCATGGACGACCTTTGGCGCTACGCTAAGATATGCCG
TGTTTCCAATGTGATGAGACCCTACCTGGAGTCACTGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0LJY5

Antitoxin

Source ID Structure
AlphaFold DB A0LJY6

References