Detailed information of TA system TA217391

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 343633..345176
• Replicon: plasmid p33.1_1
• Accession: NZ_CP083808
• Organism: Pantoea agglomerans strain 33.1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LB453_RS01570
• Protein ID: WP_103796653.1
• Coordinates: 343869..345176 (+)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LB453_RS01565
• Protein ID: WP_103796652.1
• Coordinates: 343633..343869 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LB453_RS01545 (LB453_01540)	338884..340341	+	1458	WP_103796648.1	MFS transporter	-
LB453_RS01550 (LB453_01545)	340627..341079	-	453	WP_103796649.1	hypothetical protein	-
LB453_RS01555 (LB453_01550)	341284..341856	+	573	WP_103796650.1	DUF4142 domain-containing protein	-
LB453_RS01560 (LB453_01555)	342203..343525	+	1323	WP_103796651.1	glycoside hydrolase family 10 protein	-
LB453_RS01565 (LB453_01560)	343633..343869	+	237	WP_103796652.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LB453_RS01570 (LB453_01565)	343869..345176	+	1308	WP_103796653.1	type II toxin-antitoxin system HipA family toxin	Toxin
LB453_RS01575 (LB453_01570)	345186..345962	-	777	WP_103796654.1	ABC transporter ATP-binding protein	-
LB453_RS01580 (LB453_01575)	346154..347203	+	1050	WP_103796655.1	ABC transporter substrate-binding protein	-
LB453_RS01585 (LB453_01580)	347214..348218	+	1005	WP_103796656.1	ABC transporter permease subunit	-
LB453_RS01590 (LB453_01585)	348242..349288	+	1047	WP_224481387.1	PLP-dependent cysteine synthase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	iroN / iucC / iutA	1..527897	527897

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-59)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 47902.31 Da
• Isoelectric Point: 8.6001

>T217391 WP_103796653.1 NZ_CP083808:343869-345176 [Pantoea agglomerans]
MDRLSAWMNGERVGTLTRQKNGAHLFQYAPGWLSNPLARPLSLSLPLQYPAIASVSVINFFDNLLPDNPRVRERILNRYR
AKSMQPFDLLREVGRDSVGAVMLLPEEAAAPDLTISYESLDTARLEKILSAYQSDIPLGMIPEERDFRISVAGAQEKTAL
LLTPEGWAIPHGPTPTSHIIKLPIGEIKQPFATLDMRNSVENEYVCLALARELGFRVPDASIITAGRLRALAVTRFDRRW
SADGTRLLRLPQEDICQSLGLACATKYESDGGPGIAAIMSLLMGSSNALEDRDDFMKFQVFQWLIGATDGHAKNFSLYIE
RGGSYRLTPFYDILSAYPVLGGAGLNIRELKLAMGLAASKGKKSEIDKIFPRHFLATAESVRFSTERMAQILAFFAEALP
AAVARVRQGLPAAVPPAIADAIFDNALKMASRLNK

Nucleotide

• Length: 1308 bp

>T217391 NZ_CP114201:935676-936101 [Delftia acidovorans]
ATGATCGTTGTCGATACCAACGTCATTTCGGAACTCTGGAGGCTTGCGCCCGACTCCAGAGTGCTTGCCTGGATGGACGC
CCAGGCCATTGAAACGCTGCATCTGTCTGCCGTCACCGTGGCAGAACTGCGCTACGGCATTGCAGCTATGCCTGAGGGAA
GGCGCCGCACCATCTACCAGGAGCGACTGGAGCATGAGGTTCTGCCGGCCTTCGCCGGCCGTGTCCTGGCCTTTGACCTG
GACGCGGCAAAGGCCTATGCCGATCTGATGGCGAGCGCGAAGACGCAGGGCAGGGCCATCGCCAAGGCCGATGGCTATAT
AGCGGCCACTGCCATGGCGCATGGGCTGGTGGTGGCAACGCGCGACACCAGTCCGTTCGAGGCCGGTGGGCTGCAGACCA
TCAATCCCTGGACGGCAGCGCCCTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9024.32 Da
• Isoelectric Point: 10.5597

>AT217391 WP_103796652.1 NZ_CP083808:343633-343869 [Pantoea agglomerans]
MIYSPKQLAHLIRLERQKRGWSQSDLARRVGIKQATVSNFENNPDKTTLTTLFKILQSLEQELVIQGRSAQNGKELDW

Nucleotide

• Length: 237 bp

>AT217391 NZ_CP114201:935422-935679 [Delftia acidovorans]
ATGGCCAATGTGACTGTGAGAAACCTGCCCGATGCCGTGCACCGGGCCTTGCGGGTACGCGCTGCCCACCATGGCCGCAG
TACGGAGGCGGAAATCCGCGACATTCTGGAAGCCGCCGTCCGGCCGGCAGAGCGTGTCAGGCTCGGCTCCATGCTGGCGT
CCATTGCCCGCGAGGCAGGAGGACTGACCGACTCCGAAGCCGAGGGCTTCAACCGCCTGCGCGACAGAGCGCCAGCCGAG
CCCATGGACTTTGAATGA