Detailed information of TA system TA021739

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1102234..1102931
• Replicon: chromosome
• Accession: NC_008554
• Organism: Syntrophobacter fumaroxidans MPOB

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0LGN8
• Locus tag: SFUM_RS04635
• Protein ID: WP_011697761.1
• Coordinates: 1102234..1102668 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0LGN9
• Locus tag: SFUM_RS04640
• Protein ID: WP_011697762.1
• Coordinates: 1102665..1102931 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SFUM_RS04605	1097763..1098317	+	555	WP_011697756.1	hypothetical protein	-
SFUM_RS04610	1098305..1098790	+	486	WP_041439844.1	hypothetical protein	-
SFUM_RS04615	1099073..1099729	+	657	WP_011697758.1	hypothetical protein	-
SFUM_RS22350	1099976..1100206	-	231	WP_150109430.1	hypothetical protein	-
SFUM_RS22355	1100246..1100893	-	648	WP_011697759.1	helix-turn-helix transcriptional regulator	-
SFUM_RS04630	1101107..1101709	+	603	WP_011697760.1	flavodoxin family protein	-
SFUM_RS04635	1102234..1102668	-	435	WP_011697761.1	type II toxin-antitoxin system VapC family toxin	Toxin
SFUM_RS04640	1102665..1102931	-	267	WP_011697762.1	hypothetical protein	Antitoxin
SFUM_RS04645	1103444..1104331	-	888	WP_011697763.1	LysR family transcriptional regulator	-
SFUM_RS04650	1104491..1104961	+	471	WP_150109431.1	OsmC family protein	-
SFUM_RS04655	1105142..1105498	+	357	WP_011697765.1	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-
SFUM_RS04660	1105884..1107587	-	1704	WP_011697766.1	NAD-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-133)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 16120.50 Da
• Isoelectric Point: 6.9888

>T21739 WP_011697761.1 NC_008554:c1102668-1102234 [Syntrophobacter fumaroxidans MPOB]
MILVDVNLLLYAVNQDLPQHARSRTWLETVLSGSESVGLPWVVIRAFLRITTNARIFERPLSVERAVAYVEEWLAQPVAT
TVTPGKSHWMILRNLLLDSGTGGNLTTDAHIAALAIEYGHTVYSTDNDFKRFQGLRHINPLAVQ

Nucleotide

• Length: 435 bp

>T21739 NC_008554:c1102668-1102234 [Syntrophobacter fumaroxidans MPOB]
ATGATTCTGGTGGATGTGAATCTGCTGCTCTACGCTGTGAATCAGGACCTGCCGCAACATGCCCGCTCACGTACTTGGCT
CGAGACTGTGCTGTCTGGCAGTGAAAGTGTGGGGTTGCCTTGGGTGGTTATTCGTGCCTTTTTGCGCATTACCACAAATG
CGCGAATTTTCGAACGTCCACTTTCTGTTGAACGAGCCGTTGCCTATGTTGAGGAATGGCTGGCACAGCCGGTGGCAACA
ACGGTCACACCAGGCAAAAGCCACTGGATGATCCTGCGCAATCTGCTGCTCGACTCCGGAACGGGAGGAAATCTGACAAC
AGATGCCCACATTGCCGCTCTCGCCATCGAATATGGTCACACCGTTTACTCCACGGACAACGATTTCAAGCGATTTCAAG
GATTGCGCCACATAAACCCGTTGGCGGTGCAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9824.26 Da
• Isoelectric Point: 9.8607

>AT21739 WP_011697762.1 NC_008554:c1102931-1102665 [Syntrophobacter fumaroxidans MPOB]
MRTTLTIDDEIAVSLKDLAHRSGKSFRQVVNDALRKGAHALENPEARPYRLSPTSLGLLRSNINLDKALNLADEREDAAI
AMKLELRK

Nucleotide

• Length: 267 bp

>AT21739 NC_008554:c1102931-1102665 [Syntrophobacter fumaroxidans MPOB]
ATGCGCACGACATTGACCATTGATGACGAAATCGCTGTGTCACTCAAGGATTTGGCTCATCGGAGCGGCAAGTCGTTCAG
GCAGGTGGTGAATGACGCATTACGAAAGGGGGCGCATGCACTCGAAAATCCCGAGGCTAGGCCTTACCGATTATCGCCGA
CCTCGCTGGGCCTCCTCCGCTCCAATATCAACTTGGATAAGGCGTTGAATCTGGCCGATGAGCGGGAAGATGCGGCAATC
GCCATGAAGCTGGAGCTGCGCAAATGA

Structures

Toxin

• AlphaFold DB: A0LGN8

Antitoxin

• AlphaFold DB: A0LGN9