Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2115195..2115709 Replicon chromosome
Accession NZ_CP083805
Organism Staphylococcus argenteus strain 1801221

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7JQI0
Locus tag LB317_RS10120 Protein ID WP_000233591.1
Coordinates 2115195..2115404 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag LB317_RS10125 Protein ID WP_000138932.1
Coordinates 2115416..2115709 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LB317_RS10100 (2110530) 2110530..2111894 - 1365 WP_031787694.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
LB317_RS10105 (2111909) 2111909..2112979 - 1071 WP_031787695.1 D-alanine--D-alanine ligase -
LB317_RS10110 (2113298) 2113298..2114500 + 1203 WP_031787696.1 FtsW/RodA/SpoVE family cell cycle protein -
LB317_RS10115 (2114929) 2114929..2115066 - 138 WP_000828355.1 Lmo0850 family protein -
LB317_RS10120 (2115195) 2115195..2115404 - 210 WP_000233591.1 heavy metal-associated domain-containing protein Toxin
LB317_RS10125 (2115416) 2115416..2115709 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
LB317_RS10130 (2115877) 2115877..2117361 + 1485 WP_031787697.1 cardiolipin synthase -
LB317_RS10135 (2117390) 2117390..2118037 + 648 WP_031787698.1 HD domain-containing protein -
LB317_RS10140 (2118632) 2118632..2119501 - 870 WP_000725805.1 membrane protein insertase YidC -
LB317_RS10145 (2119587) 2119587..2120228 - 642 WP_031787699.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7827.81 Da        Isoelectric Point: 4.2681

>T217387 WP_000233591.1 NZ_CP083805:c2115404-2115195 [Staphylococcus argenteus]
MVHQNTIYTAGIETEEQVNQLTERISNMIGVHKVNINIIDGEVVVAYETPANLNSIEKEIYDTGYKIVY

Download         Length: 210 bp

>T217387 NZ_CP114195:c713319-713050 [Vibrio parahaemolyticus]
ATGAGTAGTAGTCAGCGTTTACTGTCGTGGACTGATGACGCTTGGGACGACTACCTGTATTGGCAAACTCAAGACAAAAA
AACACTCAAGCGTATCAATAAACTTATCAATGATGTTAAACGTTCTCCATTTGAGGGTATCGGTAAACCTGAGCCATTGA
AAGAGAACTTATCTGGTTTTTGGTCCCGTCGTGTTGATGATACTAATAGGCTTGTTTACGCAGTCGATGATCAGGTCATA
ACGATAATCTCGTGTCGTTACCACTACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT217387 WP_000138932.1 NZ_CP083805:c2115709-2115416 [Staphylococcus argenteus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT217387 NZ_CP114195:c713566-713312 [Vibrio parahaemolyticus]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGCTCTTAAAGCTGTTTTGGACGGTGTAGTTAATGACGCTGATACAAC
AGTTATTACACGTCGTGATTCTGAAGATGCTGTGGTTATGTCCTTAGATTACTACAATAGCCTTATGGAGACAGTGCACT
TACTACGCTCTCCTCAAAACGCTGAACACTTAAACCGTTCTATAGCACAGTACCGTGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQI0

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References