Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2095059..2095588 Replicon chromosome
Accession NZ_CP083805
Organism Staphylococcus argenteus strain 1801221

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U7JQG1
Locus tag LB317_RS10035 Protein ID WP_000621178.1
Coordinates 2095059..2095421 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag LB317_RS10040 Protein ID WP_000948331.1
Coordinates 2095418..2095588 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LB317_RS10015 (2092041) 2092041..2092811 - 771 WP_001041104.1 RNA polymerase sigma factor SigB -
LB317_RS10020 (2092786) 2092786..2093265 - 480 WP_001190826.1 anti-sigma B factor RsbW -
LB317_RS10025 (2093267) 2093267..2093593 - 327 WP_001052491.1 anti-sigma factor antagonist -
LB317_RS10030 (2093710) 2093710..2094711 - 1002 WP_239794157.1 PP2C family protein-serine/threonine phosphatase -
LB317_RS10035 (2095059) 2095059..2095421 - 363 WP_000621178.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LB317_RS10040 (2095418) 2095418..2095588 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LB317_RS10045 (2095673) 2095673..2096821 - 1149 WP_001281137.1 alanine racemase -
LB317_RS10050 (2096891) 2096891..2097250 - 360 WP_031787685.1 holo-ACP synthase -
LB317_RS10055 (2097254) 2097254..2097757 - 504 WP_031787686.1 PH domain-containing protein -
LB317_RS10060 (2097744) 2097744..2099327 - 1584 WP_031787687.1 PH domain-containing protein -
LB317_RS10065 (2099320) 2099320..2099799 - 480 WP_031787688.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13502.79 Da        Isoelectric Point: 10.2892

>T217386 WP_000621178.1 NZ_CP083805:c2095421-2095059 [Staphylococcus argenteus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDNKMKEVDNALMISLGLNTMAHQKN

Download         Length: 363 bp

>T217386 NZ_CP114195:712607-712897 [Vibrio parahaemolyticus]
ATGACCTATAGACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTACAACAACAATTTAA
GAAAAAGCTAATCGACCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTTTCTGGAACTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGACGTCATCATTGTAACCATCTTAGCAGTTGGAAAA
CACGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT217386 WP_000948331.1 NZ_CP083805:c2095588-2095418 [Staphylococcus argenteus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT217386 NZ_CP114195:712369-712617 [Vibrio parahaemolyticus]
ATGACCACAAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAATCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGTGTACCTGCCGAAACGTATGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCCAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References