Detailed information of TA system TA217383

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1899212..1899999
• Replicon: chromosome
• Accession: NZ_CP083805
• Organism: Staphylococcus argenteus strain 1801221

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: A0A7U7PZK3
• Locus tag: LB317_RS08845
• Protein ID: WP_000031103.1
• Coordinates: 1899212..1899367 (-)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: LB317_RS08850
• Protein ID: WP_031787929.1
• Coordinates: 1899400..1899999 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LB317_RS08825 (1894400)	1894400..1895512	-	1113	WP_031787927.1	GAF domain-containing sensor histidine kinase	-
LB317_RS08830 (1895674)	1895674..1896495	+	822	WP_000669386.1	RluA family pseudouridine synthase	-
LB317_RS08835 (1896789)	1896789..1898174	-	1386	WP_031787928.1	class II fumarate hydratase	-
LB317_RS08840 (1898345)	1898345..1898746	-	402	WP_000901017.1	hypothetical protein	-
LB317_RS08845 (1899212)	1899212..1899367	-	156	WP_000031103.1	SAS053 family protein	Toxin
LB317_RS08850 (1899400)	1899400..1899999	-	600	WP_031787929.1	glucosamine-6-phosphate isomerase	Antitoxin
LB317_RS08855 (1900158)	1900158..1900628	-	471	WP_000181399.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
LB317_RS08860 (1900630)	1900630..1901760	-	1131	WP_031787930.1	tRNA epoxyqueuosine(34) reductase QueG	-
LB317_RS08865 (1901911)	1901911..1902633	-	723	WP_031787931.1	amino acid ABC transporter ATP-binding protein	-
LB317_RS08870 (1902626)	1902626..1904083	-	1458	WP_000649887.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 6019.42 Da
• Isoelectric Point: 4.1469

>T217383 WP_000031103.1 NZ_CP083805:c1899367-1899212 [Staphylococcus argenteus]
MSKDKDAKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKSTDEKNSH

Nucleotide

• Length: 156 bp

>T217383 NZ_CP114190:c4867658-4867407 [Aminobacter sp. NyZ550]
ATGACCCATGTAACGCTTACCGAACTGCGCGCCAACATGGCCAAATATCTCGACAAGGTCGAGGCGGACCGGACCGAACT
GGTGGTGACCAGGCAGAATCACGAGCCTGTGGTGGTCATGGCCCTGTCTGAGCTTGAAGGGTTGCGCGAAACACTGCATT
TGCTGAGCTCTCGCGCCAACGCCGAACATCTCCAGCGCTCCATTGATGAACTCAATGCCGGTTCCGGCGTCGAACGCGAT
CTCATCGAGTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22447.58 Da
• Isoelectric Point: 5.7220

>AT217383 WP_031787929.1 NZ_CP083805:c1899999-1899400 [Staphylococcus argenteus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDNKKSYFEALGV
PASQIYPIAFEKDAIEFISDKIKTKENKGKLTLQVVSIDEHGKLNVSIRQGLMEAREIFLVVTGANKKEVVEKLYQENGK
TSFEPSDLKSHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT217383 NZ_CP114190:c4867407-4867135 [Aminobacter sp. NyZ550]
ATGCGCATCATTTTTTCGGAAGCATCCTGGTCTGACTATTTGTTTTGGCAGCAGGCAGACAAAGCCGTTTGCGACCGTAT
CAATGAGCTCATCAAGGATGCCAGGCGCTCGCCCTTCGTCGGCATCGGCAAGCCGGAACCGCTTTCCGGCAACTATTCCG
GTTTCTGGTCGCGCCGCATCACGCGGGAACATCGACTCGTCTATCGGGTGACAGGCAAGGGCGATGCGCAGGCCTTGGAG
ATCGCCGCCTGCCGCTACCATTATGACCGGTAG

Structures

Toxin

• AlphaFold DB: A0A7U7PZK3