Detailed information of TA system TA217382

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 876766..877243
• Replicon: chromosome
• Accession: NZ_CP083805
• Organism: Staphylococcus argenteus strain 1801221

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: A0A7U7JTG2
• Locus tag: LB317_RS04080
• Protein ID: WP_000172413.1
• Coordinates: 876766..876954 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: A0A7U7JTE3
• Locus tag: LB317_RS04085
• Protein ID: WP_000790107.1
• Coordinates: 876983..877243 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LB317_RS04045 (872346)	872346..872828	+	483	WP_031788350.1	hypothetical protein	-
LB317_RS04050 (873171)	873171..873839	+	669	WP_031788100.1	thermonuclease family protein	-
LB317_RS04055 (874203)	874203..874403	+	201	WP_001059082.1	cold-shock protein	-
LB317_RS04060 (875016)	875016..875228	-	213	WP_001007088.1	hypothetical protein	-
LB317_RS04065 (875289)	875289..875573	-	285	WP_031788101.1	hypothetical protein	-
LB317_RS04070 (875662)	875662..876231	-	570	WP_031788102.1	lipoprotein N-acylation protein LnsA	-
LB317_RS04075 (876430)	876430..876609	+	180	WP_088808311.1	hypothetical protein	-
LB317_RS04080 (876766)	876766..876954	-	189	WP_000172413.1	hypothetical protein	Toxin
LB317_RS04085 (876983)	876983..877243	-	261	WP_000790107.1	hypothetical protein	Antitoxin
LB317_RS04090 (877583)	877583..877786	+	204	WP_000145167.1	sterile alpha motif-like domain-containing protein	-
LB317_RS04095 (877783)	877783..878019	-	237	WP_000368686.1	hypothetical protein	-
LB317_RS04100 (878244)	878244..878825	+	582	WP_031788103.1	histidine phosphatase family protein	-
LB317_RS04105 (878892)	878892..879509	-	618	WP_031788104.1	LysE family transporter	-
LB317_RS04110 (879673)	879673..880164	-	492	WP_000695603.1	GNAT family N-acetyltransferase	-
LB317_RS04115 (880571)	880571..880993	-	423	WP_001007646.1	organic hydroperoxide resistance protein	-
LB317_RS04120 (881142)	881142..881861	+	720	WP_047451209.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	vWbp	828337..890388	62051

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7192.89 Da
• Isoelectric Point: 9.9971

>T217382 WP_000172413.1 NZ_CP083805:c876954-876766 [Staphylococcus argenteus]
MTLHFAILFWLALIFIVAGTFIFVLMKKTAKESKKESYLSFAVIFYIFGFAMLIYTLIFGIL

Nucleotide

• Length: 189 bp

>T217382 NZ_CP114190:c4867407-4867135 [Aminobacter sp. NyZ550]
ATGCGCATCATTTTTTCGGAAGCATCCTGGTCTGACTATTTGTTTTGGCAGCAGGCAGACAAAGCCGTTTGCGACCGTAT
CAATGAGCTCATCAAGGATGCCAGGCGCTCGCCCTTCGTCGGCATCGGCAAGCCGGAACCGCTTTCCGGCAACTATTCCG
GTTTCTGGTCGCGCCGCATCACGCGGGAACATCGACTCGTCTATCGGGTGACAGGCAAGGGCGATGCGCAGGCCTTGGAG
ATCGCCGCCTGCCGCTACCATTATGACCGGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10089.30 Da
• Isoelectric Point: 4.1927

>AT217382 WP_000790107.1 NZ_CP083805:c877243-876983 [Staphylococcus argenteus]
MKNIQLNAINLVITIIFAIFNIMITYNKDLDDLCWLLPGIIICGSILIVSFTIAMITKFWLSEILFFINIVLVLYYIYPI
FYDFIN

Nucleotide

• Length: 261 bp

>AT217382 NZ_CP114190:c4867658-4867407 [Aminobacter sp. NyZ550]
ATGACCCATGTAACGCTTACCGAACTGCGCGCCAACATGGCCAAATATCTCGACAAGGTCGAGGCGGACCGGACCGAACT
GGTGGTGACCAGGCAGAATCACGAGCCTGTGGTGGTCATGGCCCTGTCTGAGCTTGAAGGGTTGCGCGAAACACTGCATT
TGCTGAGCTCTCGCGCCAACGCCGAACATCTCCAGCGCTCCATTGATGAACTCAATGCCGGTTCCGGCGTCGAACGCGAT
CTCATCGAGTGA

Structures

Toxin

• AlphaFold DB: A0A7U7JTG2

Antitoxin

• AlphaFold DB: A0A7U7JTE3