Detailed information of TA system TA217381

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 3944012..3944424
• Replicon: chromosome
• Accession: NZ_CP083804
• Organism: Xanthomonas translucens pv. pistacia strain ICMP 16317

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: K8O61_RS17495
• Protein ID: WP_058363817.1
• Coordinates: 3944230..3944424 (-)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: K8O61_RS17490
• Protein ID: WP_237655179.1
• Coordinates: 3944012..3944224 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8O61_RS17470 (K8O61_17475)	3939986..3940948	-	963	WP_237651483.1	IS1595 family transposase	-
K8O61_RS17475 (K8O61_17480)	3941145..3942092	-	948	WP_237655176.1	hypothetical protein	-
K8O61_RS17480 (K8O61_17485)	3942094..3943419	-	1326	WP_237655177.1	ATP-binding protein	-
K8O61_RS17485 (K8O61_17490)	3943545..3943970	-	426	WP_237655178.1	hypothetical protein	-
K8O61_RS17490 (K8O61_17495)	3944012..3944224	-	213	WP_237655179.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K8O61_RS17495 (K8O61_17500)	3944230..3944424	-	195	WP_058363817.1	type II toxin-antitoxin system HicA family toxin	Toxin
K8O61_RS17500 (K8O61_17505)	3944537..3947227	-	2691	WP_237655180.1	pyruvate dehydrogenase (acetyl-transferring), homodimeric type	-
K8O61_RS17505 (K8O61_17510)	3947463..3949403	+	1941	WP_237656104.1	SpoIIE family protein phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3931984..3949403	17419

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-62)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7003.06 Da
• Isoelectric Point: 11.0837

>T217381 WP_058363817.1 NZ_CP083804:c3944424-3944230 [Xanthomonas translucens pv. pistacia]
MPPKIRDVLQQLKDAGWQQVGQTGSHRQFKHPVYPGRVTVAGKPSDDVAPGTLNSILKQAGLKR

Nucleotide

• Length: 195 bp

>T217381 NZ_CP114190:4275082-4275375 [Aminobacter sp. NyZ550]
ATGACCATCAAGACCACAAAATGGGACGCCGCCGAGTTTCTGAACTCCAAGGAGGAAATCCTTGCCTATCTCGAGGCGGC
ATTCGAGGACGGCGACCCGTCCGGGATCAAGCTTGCCCTCAACAATGTTGCCCGGGCCCGAGGCATATCCGACCTGGCGA
GAGAAACCAAAATCTCCAGAGAGGGCATCTACAAGGCGCTGAGTGAGGATGGCGACCCAAAGCTGTCCACACTGCTCAGT
ATCGTAAAGGCGTTCGGGCTCAATCTATCGGTCAGAGACCTGGAACACGCTTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7407.32 Da
• Isoelectric Point: 3.8598

>AT217381 WP_237655179.1 NZ_CP083804:c3944224-3944012 [Xanthomonas translucens pv. pistacia]
MRYAVVIEQAGNNYSAYVPDLPGCVATGATTAEVEGLIREAIELHLAGMREDGEVIPVPSSQVEYVDVAA

Nucleotide

• Length: 213 bp

>AT217381 NZ_CP114190:4274795-4275085 [Aminobacter sp. NyZ550]
GTGATCGAAATTCGCAGGACCGCTGAGTTCACAGGCTGGCTCACCGACCTCAAGGACCTCAAGGCCAGGTCCCGCATCCT
GACCCGTATCGACCGGCTGGAGTTGGGCAACTCAGGTGATGCCAAATATTTCGACGGCATCGGCGAGCTTCGCGTCGACA
CTGGTCCTGGCTACCGCGTCTACTTCGTCAAGCGCGGCACAACTGTCGTCATCCTGCTTTGCGGTGGCGATAAGTCGACG
CAGGCTTCCGATATCAAGAAGGCCATTGCGATGGCAAAGGAGGTCAAATGA