Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3329272..3329849 Replicon chromosome
Accession NZ_CP083804
Organism Xanthomonas translucens pv. pistacia strain ICMP 16317

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag K8O61_RS14585 Protein ID WP_237654991.1
Coordinates 3329272..3329613 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag K8O61_RS14590 Protein ID WP_237654992.1
Coordinates 3329607..3329849 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O61_RS14550 (K8O61_14555) 3324562..3325305 + 744 WP_237654984.1 phage Gp37/Gp68 family protein -
K8O61_RS14555 (K8O61_14560) 3325319..3326587 + 1269 WP_237654985.1 three-Cys-motif partner protein TcmP -
K8O61_RS14560 (K8O61_14565) 3326763..3327239 - 477 WP_237654986.1 hypothetical protein -
K8O61_RS14565 (K8O61_14570) 3327253..3327591 - 339 WP_237654987.1 helix-turn-helix transcriptional regulator -
K8O61_RS14570 (K8O61_14575) 3327703..3328458 + 756 WP_237654988.1 hypothetical protein -
K8O61_RS14575 (K8O61_14580) 3328508..3328822 + 315 WP_237654989.1 hypothetical protein -
K8O61_RS14580 (K8O61_14585) 3328819..3329199 + 381 WP_237654990.1 hypothetical protein -
K8O61_RS14585 (K8O61_14590) 3329272..3329613 - 342 WP_237654991.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
K8O61_RS14590 (K8O61_14595) 3329607..3329849 - 243 WP_237654992.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
K8O61_RS14595 (K8O61_14600) 3329945..3330364 - 420 Protein_2882 integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3303331..3345229 41898


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-110)

Antitoxin

SpoVT-AbrB domain

(6-46)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12395.26 Da        Isoelectric Point: 9.8335

>T217380 WP_237654991.1 NZ_CP083804:c3329613-3329272 [Xanthomonas translucens pv. pistacia]
MVDPQWVPRRSEIIHLDDIGGAGHEQHGDRPHLVLTAKGYNDKTSLVVCVPVTTKTKGNPFEVGLKGLNNPSFALANQVI
TADWRARRAFARGIASKAEMLEVDAKVRALLQL

Download         Length: 342 bp

>T217380 NZ_CP083804:c3329613-3329272 [Xanthomonas translucens pv. pistacia]
ATGGTAGATCCCCAGTGGGTTCCTCGTCGGTCTGAAATAATTCATCTGGATGATATTGGTGGGGCCGGTCATGAGCAGCA
TGGTGACCGGCCTCACTTGGTTCTTACTGCGAAGGGATACAACGACAAGACAAGTCTTGTCGTTTGTGTTCCTGTCACAA
CTAAAACCAAAGGTAATCCTTTCGAAGTGGGTTTGAAGGGCCTGAATAATCCAAGTTTCGCACTGGCAAATCAGGTCATA
ACAGCGGACTGGCGTGCACGGAGAGCTTTTGCACGAGGGATCGCTAGCAAGGCCGAAATGCTTGAAGTCGATGCCAAGGT
TCGTGCGTTACTTCAACTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8757.89 Da        Isoelectric Point: 4.2686

>AT217380 WP_237654992.1 NZ_CP083804:c3329849-3329607 [Xanthomonas translucens pv. pistacia]
MAVLKMWGNSAAVRIPATYLEESKFSIDEPLVITAEEGRIVIESSKPSYDLADLVAQITPENTHGFAAHAQKVGAEDIEW

Download         Length: 243 bp

>AT217380 NZ_CP083804:c3329849-3329607 [Xanthomonas translucens pv. pistacia]
ATGGCTGTTTTGAAGATGTGGGGAAATAGTGCTGCGGTGCGGATTCCAGCGACTTATCTTGAGGAGTCAAAGTTTTCCAT
TGATGAGCCTCTTGTAATCACAGCCGAGGAAGGACGTATTGTGATCGAATCAAGCAAGCCTTCTTATGATCTTGCTGACT
TGGTTGCCCAAATCACTCCCGAAAACACGCACGGTTTTGCTGCTCATGCTCAAAAAGTTGGAGCGGAGGATATTGAATGG
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References