Detailed information of TA system TA217380

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 3329272..3329849
• Replicon: chromosome
• Accession: NZ_CP083804
• Organism: Xanthomonas translucens pv. pistacia strain ICMP 16317

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: K8O61_RS14585
• Protein ID: WP_237654991.1
• Coordinates: 3329272..3329613 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: K8O61_RS14590
• Protein ID: WP_237654992.1
• Coordinates: 3329607..3329849 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8O61_RS14550 (K8O61_14555)	3324562..3325305	+	744	WP_237654984.1	phage Gp37/Gp68 family protein	-
K8O61_RS14555 (K8O61_14560)	3325319..3326587	+	1269	WP_237654985.1	three-Cys-motif partner protein TcmP	-
K8O61_RS14560 (K8O61_14565)	3326763..3327239	-	477	WP_237654986.1	hypothetical protein	-
K8O61_RS14565 (K8O61_14570)	3327253..3327591	-	339	WP_237654987.1	helix-turn-helix transcriptional regulator	-
K8O61_RS14570 (K8O61_14575)	3327703..3328458	+	756	WP_237654988.1	hypothetical protein	-
K8O61_RS14575 (K8O61_14580)	3328508..3328822	+	315	WP_237654989.1	hypothetical protein	-
K8O61_RS14580 (K8O61_14585)	3328819..3329199	+	381	WP_237654990.1	hypothetical protein	-
K8O61_RS14585 (K8O61_14590)	3329272..3329613	-	342	WP_237654991.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
K8O61_RS14590 (K8O61_14595)	3329607..3329849	-	243	WP_237654992.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
K8O61_RS14595 (K8O61_14600)	3329945..3330364	-	420	Protein_2882	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3303331..3345229	41898

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-110)

Antitoxin

• SpoVT-AbrB domain (6-46)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12395.26 Da
• Isoelectric Point: 9.8335

>T217380 WP_237654991.1 NZ_CP083804:c3329613-3329272 [Xanthomonas translucens pv. pistacia]
MVDPQWVPRRSEIIHLDDIGGAGHEQHGDRPHLVLTAKGYNDKTSLVVCVPVTTKTKGNPFEVGLKGLNNPSFALANQVI
TADWRARRAFARGIASKAEMLEVDAKVRALLQL

Nucleotide

• Length: 342 bp

>T217380 NZ_CP083804:c3329613-3329272 [Xanthomonas translucens pv. pistacia]
ATGGTAGATCCCCAGTGGGTTCCTCGTCGGTCTGAAATAATTCATCTGGATGATATTGGTGGGGCCGGTCATGAGCAGCA
TGGTGACCGGCCTCACTTGGTTCTTACTGCGAAGGGATACAACGACAAGACAAGTCTTGTCGTTTGTGTTCCTGTCACAA
CTAAAACCAAAGGTAATCCTTTCGAAGTGGGTTTGAAGGGCCTGAATAATCCAAGTTTCGCACTGGCAAATCAGGTCATA
ACAGCGGACTGGCGTGCACGGAGAGCTTTTGCACGAGGGATCGCTAGCAAGGCCGAAATGCTTGAAGTCGATGCCAAGGT
TCGTGCGTTACTTCAACTTTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8757.89 Da
• Isoelectric Point: 4.2686

>AT217380 WP_237654992.1 NZ_CP083804:c3329849-3329607 [Xanthomonas translucens pv. pistacia]
MAVLKMWGNSAAVRIPATYLEESKFSIDEPLVITAEEGRIVIESSKPSYDLADLVAQITPENTHGFAAHAQKVGAEDIEW

Nucleotide

• Length: 243 bp

>AT217380 NZ_CP083804:c3329849-3329607 [Xanthomonas translucens pv. pistacia]
ATGGCTGTTTTGAAGATGTGGGGAAATAGTGCTGCGGTGCGGATTCCAGCGACTTATCTTGAGGAGTCAAAGTTTTCCAT
TGATGAGCCTCTTGTAATCACAGCCGAGGAAGGACGTATTGTGATCGAATCAAGCAAGCCTTCTTATGATCTTGCTGACT
TGGTTGCCCAAATCACTCCCGAAAACACGCACGGTTTTGCTGCTCATGCTCAAAAAGTTGGAGCGGAGGATATTGAATGG
TAG