Detailed information of TA system TA021738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 527757..528451
• Replicon: chromosome
• Accession: NC_008554
• Organism: Syntrophobacter fumaroxidans MPOB

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: SFUM_RS02230
• Protein ID: WP_150109410.1
• Coordinates: 528170..528451 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: SFUM_RS02225
• Protein ID: WP_011697308.1
• Coordinates: 527757..528122 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SFUM_RS02215	525404..526213	+	810	WP_011697306.1	phosphoribosylformylglycinamidine synthase subunit PurQ	-
SFUM_RS02220	526280..527131	+	852	WP_011697307.1	phosphoribosylglycinamide formyltransferase	-
SFUM_RS02225	527757..528122	-	366	WP_011697308.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SFUM_RS02230	528170..528451	-	282	WP_150109410.1	type II toxin-antitoxin system HicA family toxin	Toxin
SFUM_RS02235	528864..529976	-	1113	WP_167321301.1	SPASM domain-containing protein	-
SFUM_RS02240	530040..530969	-	930	WP_150109411.1	ribonuclease Z	-
SFUM_RS02245	531028..531633	-	606	WP_011697313.1	nitroreductase family protein	-
SFUM_RS02255	532102..532671	+	570	WP_011697314.1	OsmC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (29-88)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10436.86 Da
• Isoelectric Point: 7.2032

>T21738 WP_150109410.1 NC_008554:c528451-528170 [Syntrophobacter fumaroxidans MPOB]
MNEEEGLDPAQRRTLYEILENSFRAKSGWDKVEGLFRALGAGFADNGDSRIQVFLNDVVAVFHRPYTQKEIHKGALMSVK
RFLIQAGVAKPGE

Nucleotide

• Length: 282 bp

>T21738 NC_008554:c528451-528170 [Syntrophobacter fumaroxidans MPOB]
ATGAATGAAGAAGAAGGATTGGACCCGGCGCAAAGGCGAACCTTGTACGAGATCCTGGAAAACTCCTTTCGAGCGAAGTC
GGGATGGGACAAGGTCGAGGGGTTGTTTCGCGCTCTCGGAGCCGGTTTCGCCGACAACGGGGATTCCCGCATCCAGGTTT
TCCTCAACGACGTGGTCGCGGTCTTCCATCGCCCGTACACGCAAAAGGAAATCCACAAGGGGGCTCTTATGTCCGTCAAA
AGGTTCTTGATCCAGGCAGGGGTGGCAAAACCGGGAGAATAA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13820.66 Da
• Isoelectric Point: 6.4748

>AT21738 WP_011697308.1 NC_008554:c528122-527757 [Syntrophobacter fumaroxidans MPOB]
MITMRYGKYIASVEFDQQAGILYGEVTNLNDVVTFQGRSVSELEQALKESIESYLNACARFGKEPERPYTGVFQVRIRPE
VHRWAVMAAQSEGKSLNKWVSEKLEEALKGEHRIANDQPVR

Nucleotide

• Length: 366 bp

>AT21738 NC_008554:c528122-527757 [Syntrophobacter fumaroxidans MPOB]
ATGATCACGATGCGATACGGAAAATACATTGCCTCTGTCGAATTCGATCAGCAGGCAGGGATTCTCTACGGGGAAGTGAC
CAATCTCAATGACGTGGTCACGTTTCAAGGCCGCTCGGTCAGTGAGTTGGAACAGGCACTCAAGGAATCCATCGAGAGCT
ACCTGAACGCGTGCGCCAGATTCGGCAAGGAACCGGAGAGGCCGTATACGGGAGTATTCCAGGTCAGGATACGCCCGGAA
GTGCACCGATGGGCCGTCATGGCCGCACAGAGCGAAGGCAAGAGCCTGAACAAATGGGTGTCCGAAAAACTGGAGGAGGC
TCTCAAGGGAGAGCATCGCATTGCCAACGATCAGCCGGTCCGATAA