Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4764536..4765052 Replicon chromosome
Accession NZ_CP083796
Organism Klebsiella pneumoniae strain INF019 isolate INF019

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LB481_RS23460 Protein ID WP_002886902.1
Coordinates 4764536..4764820 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LB481_RS23465 Protein ID WP_002886901.1
Coordinates 4764810..4765052 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LB481_RS23435 (4759952) 4759952..4760215 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LB481_RS23440 (4760345) 4760345..4760518 + 174 WP_032410138.1 hypothetical protein -
LB481_RS23445 (4760521) 4760521..4761264 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
LB481_RS23450 (4761621) 4761621..4763759 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LB481_RS23455 (4764068) 4764068..4764532 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LB481_RS23460 (4764536) 4764536..4764820 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LB481_RS23465 (4764810) 4764810..4765052 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LB481_RS23470 (4765130) 4765130..4767040 - 1911 WP_009486549.1 PRD domain-containing protein -
LB481_RS23475 (4767063) 4767063..4768217 - 1155 WP_023302389.1 lactonase family protein -
LB481_RS23480 (4768284) 4768284..4769024 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T217371 WP_002886902.1 NZ_CP083796:c4764820-4764536 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T217371 NZ_CP114169:70105-70587 [Klebsiella variicola]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGCAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT217371 WP_002886901.1 NZ_CP083796:c4765052-4764810 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT217371 NZ_CP114169:69851-70117 [Klebsiella variicola]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References