Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 154233..154827 Replicon plasmid 1
Accession NC_008545
Organism Burkholderia cenocepacia HI2424

Toxin (Protein)


Gene name PumA Uniprot ID A0A4S3HAC4
Locus tag BCEN2424_RS34275 Protein ID WP_011695197.1
Coordinates 154233..154526 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4S3HA87
Locus tag BCEN2424_RS34280 Protein ID WP_011695198.1
Coordinates 154528..154827 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCEN2424_RS34255 149698..151827 + 2130 WP_011695192.1 ParB/RepB/Spo0J family partition protein -
BCEN2424_RS36605 152460..152855 + 396 WP_011695193.1 hypothetical protein -
BCEN2424_RS34260 152870..153136 + 267 WP_011695194.1 hypothetical protein -
BCEN2424_RS34265 153183..153662 + 480 WP_041489709.1 hypothetical protein -
BCEN2424_RS34270 153707..153928 + 222 WP_011695196.1 DUF3717 domain-containing protein -
BCEN2424_RS37285 153986..154129 + 144 WP_154641514.1 hypothetical protein -
BCEN2424_RS34275 154233..154526 + 294 WP_011695197.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BCEN2424_RS34280 154528..154827 + 300 WP_011695198.1 putative addiction module antidote protein Antitoxin
BCEN2424_RS34285 154992..155303 - 312 WP_011695199.1 hypothetical protein -
BCEN2424_RS34290 157066..157467 + 402 WP_011695200.1 hypothetical protein -
BCEN2424_RS34295 157460..159568 + 2109 WP_011695201.1 type IV secretion system DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..164857 164857


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-87)

Antitoxin

Uncharacterized protein HI1420

(4-95)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10826.43 Da        Isoelectric Point: 10.6086

>T21737 WP_011695197.1 NC_008545:154233-154526 [Burkholderia cenocepacia HI2424]
MRIEQTDDFAKWLRGLRDHIARAQIAKRIQRLARGQYGDVKSVGAGVSEMRVHVGPGYRVYFVQRGSTLVILLCGGDKST
QQRDIERAIALSAQLGD

Download         Length: 294 bp

>T21737 NC_008545:154233-154526 [Burkholderia cenocepacia HI2424]
ATGAGAATCGAGCAGACAGACGACTTCGCGAAATGGCTGCGCGGCCTACGTGACCACATCGCGCGCGCGCAGATCGCCAA
GCGGATTCAACGGCTCGCGCGCGGCCAGTACGGGGACGTGAAGTCGGTTGGTGCCGGGGTGAGCGAAATGCGCGTGCACG
TCGGCCCCGGCTATCGCGTCTACTTTGTCCAACGAGGCTCAACGCTCGTCATCCTGCTATGCGGTGGCGACAAGTCAACG
CAGCAGCGCGACATTGAGCGCGCTATCGCGCTTTCGGCGCAATTGGGAGATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10701.99 Da        Isoelectric Point: 4.6364

>AT21737 WP_011695198.1 NC_008545:154528-154827 [Burkholderia cenocepacia HI2424]
MGIKTTPFDAAEYLDTPEAQAEYLRVSFETGDSADIQEAIGTVARARGMTQIARDAGVGRESLYKALDEHGNPEFATILR
VVRALGLTLTVTTPVHEHA

Download         Length: 300 bp

>AT21737 NC_008545:154528-154827 [Burkholderia cenocepacia HI2424]
ATGGGTATCAAGACAACGCCGTTTGACGCGGCCGAATACCTCGACACGCCCGAGGCGCAGGCCGAATATCTGCGGGTTTC
GTTCGAGACTGGCGATTCTGCCGACATTCAGGAAGCCATCGGCACTGTGGCGCGTGCGCGCGGCATGACGCAGATTGCGC
GCGACGCGGGCGTTGGCCGCGAAAGCCTCTACAAAGCGCTGGACGAGCACGGCAACCCGGAATTCGCGACGATCCTGCGT
GTGGTGCGCGCGCTCGGCCTCACTTTGACCGTAACGACGCCTGTACACGAGCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S3HAC4

Antitoxin

Source ID Structure
AlphaFold DB A0A4S3HA87

References