Detailed information of TA system TA217367

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2612605..2614193
• Replicon: chromosome
• Accession: NZ_CP083796
• Organism: Klebsiella pneumoniae strain INF019 isolate INF019

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A485W5A2
• Locus tag: LB481_RS12810
• Protein ID: WP_023342812.1
• Coordinates: 2612605..2613927 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LB481_RS12815
• Protein ID: WP_024622638.1
• Coordinates: 2613927..2614193 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LB481_RS12795 (2607661)	2607661..2610162	+	2502	WP_023342811.1	fimbria/pilus outer membrane usher protein	-
LB481_RS12800 (2610150)	2610150..2611154	+	1005	WP_004224758.1	fimbrial protein	-
LB481_RS12805 (2611296)	2611296..2612588	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
LB481_RS12810 (2612605)	2612605..2613927	-	1323	WP_023342812.1	type II toxin-antitoxin system HipA family toxin	Toxin
LB481_RS12815 (2613927)	2613927..2614193	-	267	WP_024622638.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LB481_RS12820 (2614458)	2614458..2614784	-	327	WP_004184023.1	hydroxyisourate hydrolase	-
LB481_RS12825 (2614781)	2614781..2615281	-	501	WP_002904787.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LB481_RS12830 (2615259)	2615259..2616638	-	1380	WP_004184021.1	nucleobase:cation symporter-2 family protein	-
LB481_RS12835 (2616984)	2616984..2618138	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
LB481_RS12840 (2618119)	2618119..2619042	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49171.46 Da
• Isoelectric Point: 7.5358

>T217367 WP_023342812.1 NZ_CP083796:c2613927-2612605 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEVNAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T217367 NZ_CP114168:c3541826-3541494 [Klebsiella variicola]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCCGGTCACGAGCAAAGTGGAAAACGTCCGGTGCTTAT
CGTATCGAAAGCAGCGTTTAACAAGCAGACCCGGCTACCCGTTGTTGTACCCGTCACCAGCGGCGGAAACTTTGCCCGCG
CAACCGGTTTTACCGTCTCACTGGACGGCGTGGGAACAAAAACAACGGGCGTTCTTCGCTGCGACCAGCCAAGGACCATT
GTTATGGGAGCCCGGAGCGGTAAGCGGCTGGAACGCATACCTGATGCCGTTGTCAATGAGGTGCTTGCCAGGCTGGACGC
GATTCTCAGTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9924.30 Da
• Isoelectric Point: 8.5912

>AT217367 WP_024622638.1 NZ_CP083796:c2614193-2613927 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYMKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT217367 NZ_CP114168:c3542045-3541827 [Klebsiella variicola]
ATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGGGCTGTCGACGGACAGCGAAGTGGGCATGACCATTGATAATGG
CTGTCTGATTATTGAACCTCAAAAACGTCCCCGCTATTCGCTCGAAGAACTGCTGGCGCAGTGTGATCCGCACGCTGAAA
TAAGCGAAGAGGGTCGGGAATGGATTGATGCGCCTGCGGTAGGCAAGGAGATCATGTAG

Structures

Toxin

• AlphaFold DB: A0A485W5A2