Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 788772..789429 Replicon chromosome
Accession NZ_CP083796
Organism Klebsiella pneumoniae strain INF019 isolate INF019

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LB481_RS03935 Protein ID WP_002916310.1
Coordinates 789019..789429 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LB481_RS03930 Protein ID WP_002916312.1
Coordinates 788772..789038 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LB481_RS03905 (783928) 783928..785361 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LB481_RS03910 (785480) 785480..786208 - 729 WP_023342613.1 MurR/RpiR family transcriptional regulator -
LB481_RS03915 (786258) 786258..786569 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LB481_RS03920 (786733) 786733..787392 + 660 WP_002916317.1 hemolysin III family protein -
LB481_RS03925 (787543) 787543..788526 - 984 WP_023342614.1 tRNA-modifying protein YgfZ -
LB481_RS03930 (788772) 788772..789038 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LB481_RS03935 (789019) 789019..789429 + 411 WP_002916310.1 protein YgfX Toxin
LB481_RS03940 (789436) 789436..789957 - 522 WP_002916308.1 flavodoxin FldB -
LB481_RS03945 (790058) 790058..790954 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LB481_RS03950 (790977) 790977..791690 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LB481_RS03955 (791696) 791696..793429 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T217358 WP_002916310.1 NZ_CP083796:789019-789429 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T217358 NZ_CP114168:c226175-225858 [Klebsiella variicola]
ATATTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAAATAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTATGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT217358 WP_002916312.1 NZ_CP083796:788772-789038 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT217358 NZ_CP114168:c225865-225578 [Klebsiella variicola]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCGTTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGTGGAATAAAGCACCCACAAATTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References