Detailed information of TA system TA021735

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2409335..2409900
• Replicon: chromosome
• Accession: NC_008543
• Organism: Burkholderia cenocepacia HI2424

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BCEN2424_RS26300
• Protein ID: WP_011546880.1
• Coordinates: 2409529..2409900 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B1FGI9
• Locus tag: BCEN2424_RS26295
• Protein ID: WP_006752328.1
• Coordinates: 2409335..2409532 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCEN2424_RS26275	2405215..2405697	+	483	WP_011546883.1	Lrp/AsnC family transcriptional regulator	-
BCEN2424_RS26280	2405783..2407336	-	1554	WP_011546882.1	galactarate dehydratase	-
BCEN2424_RS26285	2407566..2408480	+	915	WP_011546881.1	5-dehydro-4-deoxyglucarate dehydratase	-
BCEN2424_RS26290	2408595..2409149	-	555	WP_006480480.1	hypothetical protein	-
BCEN2424_RS26295	2409335..2409532	+	198	WP_006752328.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
BCEN2424_RS26300	2409529..2409900	+	372	WP_011546880.1	PIN domain-containing protein	Toxin
BCEN2424_RS26305	2410028..2411605	-	1578	WP_011546879.1	aldehyde dehydrogenase (NADP(+))	-
BCEN2424_RS26310	2411892..2413247	+	1356	WP_166488170.1	MFS transporter	-
BCEN2424_RS26315	2413314..2414039	-	726	WP_011546877.1	site-2 protease family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-46)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13559.67 Da
• Isoelectric Point: 6.2156

>T21735 WP_011546880.1 NC_008543:2409529-2409900 [Burkholderia cenocepacia HI2424]
MILVDTSVWIDHLRAGDATLTALLEAERVLIHPFIVGELALGSMRHRETVLDALRDLPAATLATDDEVQRMIDAVPLHGL
GIGYVDAHLLASARLTSDSRLWTRDRRLLAAAERLQLVARPAH

Nucleotide

• Length: 372 bp

>T21735 NC_008543:2409529-2409900 [Burkholderia cenocepacia HI2424]
ATGATCCTTGTCGACACATCCGTCTGGATCGATCACTTGCGAGCCGGCGACGCGACGCTCACCGCCTTGCTGGAAGCGGA
GCGAGTATTGATCCATCCGTTCATCGTCGGCGAGCTTGCGCTCGGCAGCATGCGCCATCGCGAGACCGTGCTGGATGCGC
TGCGCGACCTTCCAGCTGCAACCCTTGCCACCGACGACGAAGTCCAGCGCATGATCGATGCCGTACCGCTTCACGGGCTG
GGCATCGGGTACGTCGATGCCCACCTGCTTGCGTCGGCCAGACTGACCAGCGACAGCAGGCTATGGACGCGCGACCGGCG
CCTGCTGGCGGCAGCGGAGCGCCTGCAACTCGTCGCCCGCCCCGCTCACTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7054.10 Da
• Isoelectric Point: 10.6826

>AT21735 WP_006752328.1 NC_008543:2409335-2409532 [Burkholderia cenocepacia HI2424]
MRTTLSLDDALLAKAQQLTGVTEKSALVREALRALIARESARRLARLGGTEPDLESVPRRPSEPA

Nucleotide

• Length: 198 bp

>AT21735 NC_008543:2409335-2409532 [Burkholderia cenocepacia HI2424]
ATGCGCACCACCTTGTCCCTCGACGACGCACTGCTCGCCAAAGCGCAGCAATTGACCGGCGTCACCGAAAAATCGGCGCT
CGTGAGGGAAGCGCTGCGCGCATTGATCGCCCGCGAAAGTGCGCGACGACTCGCCCGCCTCGGCGGCACCGAGCCTGATC
TTGAATCGGTCCCACGCCGCCCGTCGGAGCCCGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A2S9KMB8