Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2713744..2715332 Replicon chromosome
Accession NZ_CP083790
Organism Klebsiella variicola strain INF352

Toxin (Protein)


Gene name hipA Uniprot ID A0A1F2MCM0
Locus tag LB484_RS13360 Protein ID WP_008804919.1
Coordinates 2713744..2715066 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MCN9
Locus tag LB484_RS13365 Protein ID WP_008804920.1
Coordinates 2715066..2715332 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LB484_RS13345 (LB484_13345) 2708809..2711310 + 2502 WP_137963366.1 fimbria/pilus outer membrane usher protein -
LB484_RS13350 (LB484_13350) 2711298..2712302 + 1005 WP_117106511.1 fimbrial protein -
LB484_RS13355 (LB484_13355) 2712435..2713727 + 1293 WP_012968243.1 glycoside hydrolase family 10 protein -
LB484_RS13360 (LB484_13360) 2713744..2715066 - 1323 WP_008804919.1 type II toxin-antitoxin system HipA family toxin Toxin
LB484_RS13365 (LB484_13365) 2715066..2715332 - 267 WP_008804920.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LB484_RS13370 (LB484_13370) 2715598..2715924 - 327 WP_008804921.1 hydroxyisourate hydrolase -
LB484_RS13375 (LB484_13375) 2715921..2716421 - 501 WP_049153027.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LB484_RS13380 (LB484_13380) 2716399..2717778 - 1380 WP_012968246.1 nucleobase:cation symporter-2 family protein -
LB484_RS13385 (LB484_13385) 2718124..2719278 + 1155 WP_008804924.1 FAD-dependent urate hydroxylase HpxO -
LB484_RS13390 (LB484_13390) 2719259..2720182 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48911.26 Da        Isoelectric Point: 7.9109

>T217349 WP_008804919.1 NZ_CP083790:c2715066-2713744 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T217349 NZ_CP114164:2040691-2040793 [Klebsiella variicola]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.30 Da        Isoelectric Point: 8.5912

>AT217349 WP_008804920.1 NZ_CP083790:c2715332-2715066 [Klebsiella variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT217349 NZ_CP114164:c2040799-2040655 [Klebsiella variicola]
ACCGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2MCM0

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MCN9

References