Detailed information of TA system TA021733

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 1878606..1879129
• Replicon: chromosome
• Accession: NC_008543
• Organism: Burkholderia cenocepacia HI2424

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BCEN2424_RS24115
• Protein ID: WP_011547274.1
• Coordinates: 1878863..1879129 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1K8I6
• Locus tag: BCEN2424_RS24110
• Protein ID: WP_011547275.1
• Coordinates: 1878606..1878866 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCEN2424_RS24080	1873964..1875172	-	1209	WP_011547280.1	acetate/propionate family kinase	-
BCEN2424_RS24085	1875183..1876151	-	969	WP_011547279.1	phosphate acetyltransferase	-
BCEN2424_RS24090	1876297..1877172	+	876	WP_011547278.1	ATP synthase F1 subunit gamma	-
BCEN2424_RS24095	1877183..1877641	+	459	WP_011694794.1	ATP synthase F1 subunit epsilon	-
BCEN2424_RS35880	1877664..1878383	-	720	Protein_1696	GNAT family N-acetyltransferase	-
BCEN2424_RS24110	1878606..1878866	+	261	WP_011547275.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
BCEN2424_RS24115	1878863..1879129	+	267	WP_011547274.1	Txe/YoeB family addiction module toxin	Toxin
BCEN2424_RS24120	1879179..1879802	+	624	WP_011547273.1	HAD hydrolase-like protein	-
BCEN2424_RS24125	1880209..1880787	+	579	WP_011547272.1	DUF4142 domain-containing protein	-
BCEN2424_RS24130	1880909..1881508	-	600	WP_041489366.1	GNAT family N-acetyltransferase	-
BCEN2424_RS24135	1881569..1882483	-	915	WP_011547270.1	LysR family transcriptional regulator	-
BCEN2424_RS24140	1882592..1883830	+	1239	WP_011547269.1	diaminopimelate decarboxylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10556.88 Da
• Isoelectric Point: 7.9861

>T21733 WP_011547274.1 NC_008543:1878863-1879129 [Burkholderia cenocepacia HI2424]
MSVRRVLFTSDAWDDYVYWQGQDRKTLKRINQLIRETQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQISI
VSCRYHYE

Nucleotide

• Length: 267 bp

>T21733 NC_008543:1878863-1879129 [Burkholderia cenocepacia HI2424]
ATGAGCGTACGTCGCGTGCTCTTTACTTCCGACGCATGGGATGACTATGTCTACTGGCAAGGACAGGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAACCCAGCGCACGCCGTTCGAAGGCATCGGCAAGCCGGAGCCGTTGAAAGCCA
ATCTGTCCGGCTTCTGGTCGCGCCGCATCGACGATACGAACCGCCTGGTCTACGAGGCTGACGACCTTCAAATCAGCATC
GTGTCCTGTCGCTACCATTACGAGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9745.00 Da
• Isoelectric Point: 6.0717

>AT21733 WP_011547275.1 NC_008543:1878606-1878866 [Burkholderia cenocepacia HI2424]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAEDDE

Nucleotide

• Length: 261 bp

>AT21733 NC_008543:1878606-1878866 [Burkholderia cenocepacia HI2424]
ATGCGCACGATTCATTTTTCCGATGCCCGCGGCAATCTGAAGACCGTCATCGACCAGGTCGTCGACGATGCGGACGTGAC
GCTCATTACGCGCCGCGATGCACCGAACGCCGTCATCATGTCGCAGGACTATTACGACAGCCTGATGGAGACGGTTCACC
TGCTGCGCTCGCCAGCCAACGTCGCTCATCTCGAACGTTCGATCGCGCAACTGCGCAAGGGCAAGGCGAAAGAACACAAG
CTCGCCGAGGACGATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1J9NJ62